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504905 Memantine Hydrochloride - CAS 41100-52-1 - Calbiochem

Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

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Synonyme: 3,5-Dimethyl-1-adamantanamine hydrochloride

Primary Target: NMDA receptors
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504905
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
41100-52-1C₁₂H₂₁N•HCl

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      Description
      OverviewA very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
      Catalogue Number504905
      Brand Family Calbiochem®
      Synonyms3,5-Dimethyl-1-adamantanamine hydrochloride
      References
      ReferencesLimapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
      Anand, A., et al. 2012. Bipolar Dis. 14, 64.
      Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
      Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
      Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
      Lee, G., et al. 2012. Psychiatry Investig. 9, 166.
      Product Information
      CAS number41100-52-1
      FormWhite solid
      Hill FormulaC₁₂H₂₁N•HCl
      Chemical formulaC₁₂H₂₁N•HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.04905.0001 04055977263633

      Documentation

      Memantine Hydrochloride - CAS 41100-52-1 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Limapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
      Anand, A., et al. 2012. Bipolar Dis. 14, 64.
      Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
      Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
      Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
      Lee, G., et al. 2012. Psychiatry Investig. 9, 166.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2013 JSW
      Synonyms3,5-Dimethyl-1-adamantanamine hydrochloride
      DescriptionA very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
      FormWhite solid
      CAS number41100-52-1
      Chemical formulaC₁₂H₂₁N•HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLimapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
      Anand, A., et al. 2012. Bipolar Dis. 14, 64.
      Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
      Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
      Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
      Lee, G., et al. 2012. Psychiatry Investig. 9, 166.