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504635 MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem

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Synonyme: 6-Methyl-2-(phenylethynyl)pyridine hydrochloride

Primary Target: mGlu₅ receptors
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      96206-92-7C₁₄H₁₁N Å• HCl
      Description
      Overview

      This product has been discontinued.



      A non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36 nM). Also a positive allosteric modulator of mGlu4and weak anatagonist of NMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
      Catalogue Number504635
      Brand Family Calbiochem®
      Synonyms6-Methyl-2-(phenylethynyl)pyridine hydrochloride
      References
      ReferencesManago, F., et al. 2013. Psychopharmacol. (Berl) 226, 541.
      Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry. 40, 18.
      Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England) 1, 355.
      Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics. 319, 254.
      Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol. 132, 1423.
      Product Information
      CAS number96206-92-7
      FormWhite to off-white solid
      Hill FormulaC₁₄H₁₁N Å• HCl
      Chemical formulaC₁₄H₁₁N Å• HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₅ receptors
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      504635 0

      Documentation

      MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Manago, F., et al. 2013. Psychopharmacol. (Berl) 226, 541.
      Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry. 40, 18.
      Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England) 1, 355.
      Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics. 319, 254.
      Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol. 132, 1423.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-August-2020 JSW
      Synonyms6-Methyl-2-(phenylethynyl)pyridine hydrochloride
      DescriptionA non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36 nM). Also a positive allosteric modulator of mGlu4and weak anatagonist of NMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
      FormWhite to off-white solid
      CAS number96206-92-7
      Chemical formulaC₁₄H₁₁N Å• HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesManago, F., et al. 2013. Psychopharmacol. (Berl) 226, 541.
      Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry. 40, 18.
      Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England) 1, 355.
      Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics. 319, 254.
      Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol. 132, 1423.