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SCC470 MOC2 Mouse Oral Squamous Cell Carcinoma (OSCC) Cell Line

The MOC (Mouse Oral Cancer) cell lines provide a syngeneic HNSCC cancer model that can be transplanted into C57BL/6 mice. These lines are important models for immune cell infiltration applications. The MOC lines have been utilized to compare and identify potential clinical scenarios that are applicable to human Oral Squamous Cell Carcinoma.The MOC2 cell line was derived from primary tumors in a C57BL/6 WT mouse and demonstrates an aggressive growth phenotype and decreased MHC I expression.

SCC470
≥1X10⁶ cells/vial   
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      Replacement Information
      Description
      Catalogue NumberSCC470
      DescriptionMOC2 Mouse Oral Squamous Cell Carcinoma (OSCC) Cell Line
      Alternate Names
      • MOC2 cell line
      • mouse oral carcinoma 2 cell line
      • oral carcinoma cell line
      Background InformationDespite ongoing efforts to understand growth and signaling pathways in head and neck squamous cell carcinoma (HNSCC), patient outcomes have remained largely unchanged in recent decades. A significant barrier to understanding and studying immune responses in the context of cancer in recent years has been the lack of available syngeneic mouse models. Xenograft approaches have historically been popular models, but they unfortunately do not model important adapative immunity responses.

      The MOC2 cell line expresses CD44, which has been implicated as a cancer stem cell marker that typically characterizes tumors with higher resistance to therapeutic treatment, at a higher level when compared to the MOC1 cell line. The MOC2 cell line generates a tumor microenvironment with lower CD8+ T cell levels The MOC2 cell line exhibits a more aggressive growth pattern than the more indolent growth observed with MOC1 cells.

      The MOC cell lines have expanded our understanding of CXCL14 downregulation in metastatic lymph nodes. Previously, CXCL14 expression had been associated with T-cell associated mechanisms for tumor suppression. Tumor Infiltrating Lymphocyte (TIL) studies using MOC1 and MOC2 have found a cell-specific association in Oral Squamous Cell Carcinomas (OSCCs) involving CXCL14 downregulation resulting in TIL increase which leads to tumor suppression.

      The MOC group of cell lines contained common HNSCC mutations in addition to human-related OSCC driver pathways. All MOC lines share RAS pathway mutations and MOC22 was found to have HRAS mutations which is relevant in relation to human HRAS-mutant OSCC groups.

      Source:
      The MOC2 cell line was derived from carcinogen-induced oral tumors in immunocompetent C57BL/6 mice.

      References:
      1. Judd, N. P., Allen, C. T., Winkler, A. E., & Uppaluri, R. (2012). Comparative analysis of tumor-infiltrating lymphocytes in a syngeneic mouse model of oral cancer. Otolaryngology--Head and Neck Surgery, 147(3), 493-500.
      2. Parikh, A., Shin, J., Faquin, W., Lin, D. T., Tirosh, I., Sunwoo, J. B., & Puram, S. V. (2020). Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma. Journal for ImmunoTherapy of Cancer, 8(2).​
      3. Onken, M. D., Winkler, A. E., Kanchi, K. L., Chalivendra, V., Law, J. H., Rickert, C. G., ... & Uppaluri, R. (2014). A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. Clinical Cancer Research, 20(11), 2873-2884.
      References
      Product Information
      Components
      • ≥1x106 viable MOC2 Cells: (Catalog No. SCC470). Store in liquid nitrogen.
      Quality LevelMQ100
      Applications
      ApplicationThe MOC (Mouse Oral Cancer) cell lines provide a syngeneic HNSCC cancer model that can be transplanted into C57BL/6 mice. These lines are important models for immune cell infiltration applications. The MOC lines have been utilized to compare and identify potential clinical scenarios that are applicable to human Oral Squamous Cell Carcinoma.The MOC2 cell line was derived from primary tumors in a C57BL/6 WT mouse and demonstrates an aggressive growth phenotype and decreased MHC I expression.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@milliporesigma.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥1X10⁶ viable cells.
      • MOC2 cells are verified to be of mouse origin and negative for human, rat, Chinese hamster, Golden Syrian hamster, and non-human primate interspecies contamination, as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      • Cells tested negative for infectious diseases against a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells tested negative for mycoplasma.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMOC2 cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      SCC470 04065269282907