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444285 MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem

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Synonyme: (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS

Primary Target: MMP-2
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      869577-53-7C₁₆H₁₇NO₅S₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 µM, 295 µM, and > 25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and > 25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
      Catalogue Number444285
      Brand Family Calbiochem®
      Synonyms(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
      References
      ReferencesIkejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.
      Product Information
      CAS number869577-53-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₁₇NO₅S₃
      Chemical formulaC₁₆H₁₇NO₅S₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-2
      Primary Target K<sub>i</sub>16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively
      Purity≥85% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      444285 0

      Documentation

      MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      444285

      Literatur

      Übersicht
      Ikejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms(4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
      DescriptionA cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 µM, 295 µM, and >25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and >25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number869577-53-7
      Chemical formulaC₁₆H₁₇NO₅S₃
      Structure formulaStructure formula
      Purity≥85% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesIkejiri, M., et al. 2005. J. Biol. Chem. 280, 33992.