Millipore Sigma Vibrant Logo

538437 MGAT2 Inhibitor, Cpd24d - Calbiochem

A cell-permeable, bioavailable, highly potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 inhibitor (MGAT2, IC₅₀ = 3.4 nM). Displays good microsomal stability.

MGAT2 Inhibitor, Cpd24d - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 5-(N-(2,4-difluorophenyl)sulfamoyl)-7-(2-oxopyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)indoline-1-carboxamide , Acyl CoA:monoacylglycerol acyltransferase 2 inhibitor, Cpd24d

Primary Target: MGAT2
View Products on Sigmaaldrich.com
538437
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₂₁F₅N₄O₄S

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
5.38437.0001
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Glasflasche 5 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      Description
      OverviewA cell-permeable, bioavailable, indoline derivative that acts as a highly potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 inhibitor (MGAT2, IC50 = 3.4 nM). Displays good microsomal stability and desirable pharmacokinetic properties (F = 52%; AUC 0 - 8 h = 842 ng/h/ml). Effectively suppresses the elevation of plasma triacylglyceride levels after olive oil challenge in C57BL/6J mice (10 - 30 mg/kg; p.o.).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number538437
      Brand Family Calbiochem®
      Synonyms5-(N-(2,4-difluorophenyl)sulfamoyl)-7-(2-oxopyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)indoline-1-carboxamide , Acyl CoA:monoacylglycerol acyltransferase 2 inhibitor, Cpd24d
      References
      ReferencesSato, K., et al. 2015. J. Med. Chem. 58, 3892.
      Product Information
      FormWhite solid
      Hill FormulaC₂₆H₂₁F₅N₄O₄S
      Chemical formulaC₂₆H₂₁F₅N₄O₄S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMGAT2
      Primary Target IC<sub>50</sub>3.4 nM for MGAT inhibition
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.38437.0001 04054839119606

      Documentation

      MGAT2 Inhibitor, Cpd24d - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Sato, K., et al. 2015. J. Med. Chem. 58, 3892.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-July-2017 JSW
      Synonyms5-(N-(2,4-difluorophenyl)sulfamoyl)-7-(2-oxopyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)indoline-1-carboxamide , Acyl CoA:monoacylglycerol acyltransferase 2 inhibitor, Cpd24d
      DescriptionA cell-permeable, bioavailable, indoline derivative that acts as a highly potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 inhibitor (MGAT2, IC50 = 3.4 nM). Displays good microsomal stability and desirable pharmacokinetic properties (F = 52%; AUC 0 - 8 h = 842 ng/h/ml). Effectively suppresses the elevation of plasma triacylglyceride levels after olive oil challenge in C57BL/6J mice (10 - 30 mg/kg; p.o.).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₂₁F₅N₄O₄S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSato, K., et al. 2015. J. Med. Chem. 58, 3892.