474787 Sigma-AldrichMG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem
MG-132, ≥95% by HPLC, CAS 133407-82-6, is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM).
More>> MG-132, ≥95% by HPLC, CAS 133407-82-6, is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: Proteasome Inhibitor XI, Z-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 133407-82-6 | C₂₆H₄₁N₃O₅ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 474787-10MG |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474790) is also available. Also available as a 20 mM solution in DMSO (Cat. No. 474788). |
| Catalogue Number | 474787 |
| Brand Family | Calbiochem® |
| Synonyms | Proteasome Inhibitor XI, Z-Leu-Leu-Leu-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal |
| Product Information | |
|---|---|
| CAS number | 133407-82-6 |
| Form | White powder |
| Hill Formula | C₂₆H₄₁N₃O₅ |
| Chemical formula | C₂₆H₄₁N₃O₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | MG-132, ≥95% by HPLC, CAS 133407-82-6, is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). |
| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 474787-10MG | 04055977185454 |
Documentation
MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 474787 |
Literatur
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| Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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