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444155 MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem

The MDMX Antagonist, SJ-172550, also referenced under CAS 431979-47-4, controls the biological activity of MDMX.

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Synonyme: Methyl-2-(2-chloro-6-ethoxy-4-(E)-(3-methyl-5-oxo-1-phenyl-pyrazol-4-ylidene)methyl)phenoxy)acetate, MDMX Inhibitor II

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      431979-47-4C₂₂H₂₁ClN₂O₅
      Description
      OverviewA cell-permeable phenyl-pyrazolylidene compound that competes with p53-derived peptide (aa 15-29) binding to MDMX in cell-free binding assays (EC50 = 2.3 µM) in a reversible manner and effectively disrupts cellular p53-MDMX interaction (IC50 <20 µM in C33A, HER, and Weri1 cultures), while exhibiting much weaker affinity toward MDM2 (EC50 = 26 µM in p53 peptide competition assays). MDMX inhibition by 20 µM SJ-172550 and MDM2 inhibition by 5 µM Nutlin-3a (Cat. Nos. 444143 & 444151) are both shown to result in reduced proliferation and increased cellular caspase-3 in cultured cells, however, only MDM2, but not MDMX, inhibition results in a significant p53 protein level upregulation.
      Catalogue Number444155
      Brand Family Calbiochem®
      SynonymsMethyl-2-(2-chloro-6-ethoxy-4-(E)-(3-methyl-5-oxo-1-phenyl-pyrazol-4-ylidene)methyl)phenoxy)acetate, MDMX Inhibitor II
      References
      ReferencesReed, D., et al. 2010. J. Biol. Chem. 285, 10786.
      Product Information
      CAS number431979-47-4
      FormOrange solid
      Hill FormulaC₂₂H₂₁ClN₂O₅
      Chemical formulaC₂₂H₂₁ClN₂O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      444155 0

      Documentation

      MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      444155

      Literatur

      Übersicht
      Reed, D., et al. 2010. J. Biol. Chem. 285, 10786.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-September-2012 JSW
      SynonymsMethyl-2-(2-chloro-6-ethoxy-4-(E)-(3-methyl-5-oxo-1-phenyl-pyrazol-4-ylidene)methyl)phenoxy)acetate, MDMX Inhibitor II
      DescriptionA cell-permeable phenyl-pyraz-olylidene compound that competes with p53-derived peptide (aa 15-29) binding to MDMX in cell-free binding assays (EC50 = 2.3 µM) in a reversible manner and effectively disrupts cellular p53-MDMX interaction (IC50 <20 µM in C33A, HER, and Weri1 cultures), while exhibiting much weaker affinity toward MDM2 (EC50 = 26 µM in p53 peptide competition assays). MDMX inhibition by 20 µM SJ-172550 and MDM2 inhibition by 5 µM Nutlin-3a (Cat. Nos. 444143 & 444151) are both shown to result in reduced proliferation and increased cellular caspase-3 in cultured cells, however, only MDM2, but not MDMX, inhibition results in a significant p53 protein level upregulation.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number431979-47-4
      Chemical formulaC₂₂H₂₁ClN₂O₅
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesReed, D., et al. 2010. J. Biol. Chem. 285, 10786.