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429705 Leptin, Mouse, Recombinant, E. coli

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429705
  
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      Description
      Overview

      This product has been discontinued.



      Recombinant, mouse leptin espressed in E. coli. Native leptin is a product of the obese (ob) gene that serves as a ligand for the OB receptor (OB-R). Mice with mutations in the ob gene have been found to be obese and diabetic and to have reduced activity, metabolism and body temperature. Suppresses insulin secretion by inhibiting activities of Ca2+-dependent PKC isoforms. Reported to reduce hepatic glucose production by blocking phosphoenolpyruvate synthesis.

      Catalogue Number429705
      Brand Family Calbiochem®
      SynonymsβrmOB
      References
      ReferencesAnderwald, C., et al. 2002. Mol. Endocrinol. 16, 1612.
      Ookuma, M., et al. 1998. Diabetes 47, 219.
      Campfield, L.A., et al. 1995. Science 269, 546.
      Halaas, J.L., et al. 1995. Science 269, 543.
      Pelleymounter, M.A., et al. 1995. Science 269, 540.
      Zhang, Y., et al. 1994. Nature 372, 425.
      Product Information
      CAS number181030-10-4
      FormLyophilized
      FormulationLyophilized from a sterile filtered PBS.
      Quality LevelMQ100
      Biological Information
      Biological activityED₅₀ = 0.2-1 ng/ml as measured by its ability to induce proliferation of leptin-dependent rOB-R transfected murine BAF3 cells
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg leptin
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C or -70°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C or -70°C. Avoid freeze/thaw cycles of solutions.
      Global Trade Item Number
      Bestellnummer GTIN
      429705 0