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509705 L-Serine-O-phosphate - CAS 407-41-0 - Calbiochem

A potent agonist for group III mGlu receptor subtype 4, 6, and 8.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: L-2-Amino-3-hydroxypropanoic acid 3-phosphate, L-SOP, L-Serine O-phosphate

Primary Target: mGlu₄, mGlu₆, mGlu₈
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      407-41-0C₃H₈NO₆P
      Description
      Overview

      This product has been discontinued.



      A potent agonist for group III mGlu receptor subtype 4, 6, and 8 (EC50 = 1-4, 3, and 2 µM for mGlu4, mGlu6, mGlu8, respectively); but not for subtype 7 (EC50 = 160-1200 µM). Inhibits proliferation and enhances neuronal differentiation in progenitor cells. Widely used to study presynaptic inhibitory modulation of the excitatory glutamatergic transmission at retina and central nervous systems.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509705
      Brand Family Calbiochem®
      SynonymsL-2-Amino-3-hydroxypropanoic acid 3-phosphate, L-SOP, L-Serine O-phosphate
      References
      ReferencesEriksen, L., et al. 1995. Br. J. Pharmacol. 116, 3279.
      Thoreson, W., et al. 1995. Brain Res. 676, 93.
      Bruno, V., et al. 1996. Eur. J. Pharmacol. 310, 61.
      Saxe, J., et al. 2007. Chem. Biol. 14, 1019.
      Nakajima, Y., 1993. J. Biol. Chem. 268, 11868.
      Product Information
      CAS number407-41-0
      FormOff-white powder
      Hill FormulaC₃H₈NO₆P
      Chemical formulaC₃H₈NO₆P
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₄, mGlu₆, mGlu₈
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      509705 0

      Documentation

      L-Serine-O-phosphate - CAS 407-41-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Eriksen, L., et al. 1995. Br. J. Pharmacol. 116, 3279.
      Thoreson, W., et al. 1995. Brain Res. 676, 93.
      Bruno, V., et al. 1996. Eur. J. Pharmacol. 310, 61.
      Saxe, J., et al. 2007. Chem. Biol. 14, 1019.
      Nakajima, Y., 1993. J. Biol. Chem. 268, 11868.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2014 JSW
      SynonymsL-2-Amino-3-hydroxypropanoic acid 3-phosphate, L-SOP, L-Serine O-phosphate
      DescriptionA potent agonist for group III mGlu receptor subtype 4, 6, and 8 (EC50 = 1-4, 3, and 2 µM for mGlu4, mGlu6, mGlu8, respectively); but not for subtype 7 (EC50 = 160-1200 µM). Inhibits proliferation and enhances neuronal differentiation in progenitor cells. Widely used to study presynaptic inhibitory modulation of the excitatory glutamatergic transmission at retina and central nervous systems.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number407-41-0
      Chemical formulaC₃H₈NO₆P
      Purity≥98% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEriksen, L., et al. 1995. Br. J. Pharmacol. 116, 3279.
      Thoreson, W., et al. 1995. Brain Res. 676, 93.
      Bruno, V., et al. 1996. Eur. J. Pharmacol. 310, 61.
      Saxe, J., et al. 2007. Chem. Biol. 14, 1019.
      Nakajima, Y., 1993. J. Biol. Chem. 268, 11868.