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505027 Kynurenic Acid Sodium Salt - CAS 196901 - Calbiochem

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Synonyme: Ionotropic Glutamate Receptor Antagonist, Kynurenic Acid Sodium Salt, 4-Hydroxyquinoline-2-carboxylic acid sodium salt

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      2439-02-3C₁₀H₆NNaO₃
      Description
      Overview

      This product has been discontinued.



      An endogenous antagonist of ionotropic AMPA, NMDA and kainate glutamate receptors, a noncompetitive antagonist at the glycine site of the NMDA receptor, and a ligand for the orphan G protein-coupled receptor GPR35. Often used for blocking kainic acid neurotoxicity. Proposed to be involved in the pathophysiology and pathogenesis of schizophrenia.
      Catalogue Number505027
      Brand Family Calbiochem®
      SynonymsIonotropic Glutamate Receptor Antagonist, Kynurenic Acid Sodium Salt, 4-Hydroxyquinoline-2-carboxylic acid sodium salt
      References
      ReferencesSchwarcz, R., et al. 2010. Neuropsychopharmacol. 35, 1734.
      Mok, H., et al. 2009. Neuropharmacol. 57, 242.
      Erhardt, S., et al. 2007. Physiol. Behav. 92, 203.
      Wang, J., et al. 2006. J. Biol. Chem. 281, 22021.
      Stone, W., 1993. Pharmacol. Rev. 45, 309.
      Product Information
      CAS number2439-02-3
      FormOff-white solid
      Hill FormulaC₁₀H₆NNaO₃
      Chemical formulaC₁₀H₆NNaO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      505027 0

      Documentation

      Kynurenic Acid Sodium Salt - CAS 196901 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Schwarcz, R., et al. 2010. Neuropsychopharmacol. 35, 1734.
      Mok, H., et al. 2009. Neuropharmacol. 57, 242.
      Erhardt, S., et al. 2007. Physiol. Behav. 92, 203.
      Wang, J., et al. 2006. J. Biol. Chem. 281, 22021.
      Stone, W., 1993. Pharmacol. Rev. 45, 309.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2016 JSW
      SynonymsIonotropic Glutamate Receptor Antagonist, Kynurenic Acid Sodium Salt, 4-Hydroxyquinoline-2-carboxylic acid sodium salt
      DescriptionAn endogenous antagonist of ionotropic AMPA, NMDA and kainate glutamate receptors, a noncompetitive antagonist at the glycine site of the NMDA receptor, and a ligand for the orphan G protein-coupled receptor GPR35. Often used for blocking kainic acid neurotoxicity. Proposed to be involved in the pathophysiology and pathogenesis of schizophrenia.
      FormOff-white solid
      CAS number2439-02-3
      Chemical formulaC₁₀H₆NNaO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchwarcz, R., et al. 2010. Neuropsychopharmacol. 35, 1734.
      Mok, H., et al. 2009. Neuropharmacol. 57, 242.
      Erhardt, S., et al. 2007. Physiol. Behav. 92, 203.
      Wang, J., et al. 2006. J. Biol. Chem. 281, 22021.
      Stone, W., 1993. Pharmacol. Rev. 45, 309.