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420120 Juglone - CAS 481-39-0 - Calbiochem

A highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family).

Juglone - CAS 481-39-0 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone

Primary Target: PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family)
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420120
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
481-39-0C₁₀H₆O₃

Preis & Verfügbarkeit

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420120-250MG
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      Description
      OverviewA highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family). Other known PPlase inhibitors such as cyclosporin A, FK506, and rapamycin are not reported to inhibit the parvulin family of PPlases. The inactivation is shown to occur via the addition of thiol groups to juglone and not by any redox process. Exhibits bacteriostatic and fungistatic effects. Reported to be cytotoxic towards eukaryotic cells and to block transcription by RNA polymerase II.
      Catalogue Number420120
      Brand Family Calbiochem®
      Synonyms5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
      References
      ReferencesChao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
      Hennig, L., et al. 1998. Biochemistry 37, 5953.
      Product Information
      CAS number481-39-0
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₁₀H₆O₃
      Chemical formulaC₁₀H₆O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQJ5775000
      Safety Information
      R PhraseR: 36/37/38-25

      Irritating to eyes, respiratory system and skin.
      Toxic if swallowed.
      S PhraseS: 45-26

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      420120-250MG 04055977188004

      Documentation

      Juglone - CAS 481-39-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Juglone - CAS 481-39-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      420120

      Literatur

      Übersicht
      Chao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
      Hennig, L., et al. 1998. Biochemistry 37, 5953.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      Synonyms5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
      DescriptionOriginally isolated from the fruit shells and leaves of walnut trees, juglone is a highly selective, cell permeable, irreversible inhibitor of the parvulin family of peptidyl-prolyl cis/trans isomerases (PPIase). Functions by covalently modifying sulfhydryl groups in the target enzymes. Exhibits bacteriostatic and fungistatic properties as well as cytotoxicity in eukaryotic cells. Also reported to directly block transcription in eukaryotic cells by RNA polymerase I, II, and III as determined by nuclear run-off (IC50 = 7 µM, 7 µM, and 2 µM, respectively). Disrupts formation of functional pre-initiation complexes via modification of sulhydryl groups, but does not significantly affect initiation or elongation. Does not inhibit restriction endonucleases or T7 RNA polymerase.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number481-39-0
      RTECSQJ5775000
      Chemical formulaC₁₀H₆O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 5269
      ReferencesChao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
      Hennig, L., et al. 1998. Biochemistry 37, 5953.