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420133 JNK Inhibitor VI, TI-JIP153-163 - Calbiochem

The JNK Inhibitor VI, TI-JIP153-163 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: H₂N-RPKRPTTLNLF-NH₂, Truncated Inhibitor based on JNK-Interacting Protein 1

Primary Target: JNK
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₆₁H₁₀₄N₂₀O₁₄
      Description
      Overview

      This product has been discontinued.



      A murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134).
      Catalogue Number420133
      Brand Family Calbiochem®
      SynonymsH₂N-RPKRPTTLNLF-NH₂, Truncated Inhibitor based on JNK-Interacting Protein 1
      References
      ReferencesBarr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₁H₁₀₄N₂₀O₁₄
      Chemical formulaC₆₁H₁₀₄N₂₀O₁₄
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJNK
      Primary Target IC<sub>50</sub>KD in low µM range
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      420133 0

      Documentation

      JNK Inhibitor VI, TI-JIP153-163 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      JNK Inhibitor VI, TI-JIP153-163 - Calbiochem Analysenzertifikate

      TitelChargennummer
      420133

      Literatur

      Übersicht
      Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-July-2008 RFH
      SynonymsH₂N-RPKRPTTLNLF-NH₂, Truncated Inhibitor based on JNK-Interacting Protein 1
      DescriptionA murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134).
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₁H₁₀₄N₂₀O₁₄
      Peptide SequenceH-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBarr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.