420136 Sigma-AldrichJNK Inhibitor IX - CAS 312917-14-9 - Calbiochem
The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 312917-14-9 | C₂₀H₁₆N₂OS • H₂O |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 420136-5MG |
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Kst.-Ampulle | 5 mg |
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| Description | |
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| Overview | A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50 <5.0). In contrast, SP600125 (Cat. Nos. 420119 and 420128) offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions. |
| Catalogue Number | 420136 |
| Brand Family | Calbiochem® |
| Synonyms | N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide |
| References | |
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| References | Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296. |
| Product Information | |
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| CAS number | 312917-14-9 |
| ATP Competitive | Y |
| Form | Tan solid |
| Hill Formula | C₂₀H₁₆N₂OS • H₂O |
| Chemical formula | C₂₀H₁₆N₂OS • H₂O |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | JNK2 and JNK3 |
| Primary Target IC<sub>50</sub> | pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 420136-5MG | 04055977187663 |
Documentation
JNK Inhibitor IX - CAS 312917-14-9 - Calbiochem SDB
| Titel |
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JNK Inhibitor IX - CAS 312917-14-9 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 420136 |
Literatur
| Übersicht |
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| Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296. |
Posters
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| Human Kinome & InhibitorSelect™ Libraries |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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