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407271 Integrin αMβ₂ Ligand - CAS 307525-40-2 - Calbiochem

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Synonyme: 3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I

Primary Target: Binds to and stabilizes integrin αM I domain active conformation
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      307525-40-2C₁₉H₁₅NOS₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable thioxothiazolidine compound that displays anti-inflammatory properties. Shown to increase cell adhesion and lowers leukemia cell migration in vitro and leukocyte recruitment in vivo and displays anti-inflammatory properties. Binds to and stabilizes integrin αM I domain active conformation and enhances the ligands' (pro-MMP-9 and fibrinogen) binding ability.
      Catalogue Number407271
      Brand Family Calbiochem®
      Synonyms3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I
      References
      ReferencesBjorklund, M., et al. 2006. Biochemistry 45, 2862.
      Product Information
      CAS number307525-40-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₅NOS₂
      Chemical formulaC₁₉H₁₅NOS₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBinds to and stabilizes integrin αM I domain active conformation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      407271 0

      Documentation

      Literatur

      Übersicht
      Bjorklund, M., et al. 2006. Biochemistry 45, 2862.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I
      DescriptionA cell-permeable thioxothiazolidine compound that displays anti-inflammatory properties. Shown to increase cell adhesion and lowers leukemia cell migration in vitro and leukocyte recruitment in vivo and displays anti-inflammatory properties. Binds to and stabilizes integrin αM I domain active conformation and enhances the ligands' (pro-MMP-9 and fibrinogen) binding ability.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number307525-40-2
      Chemical formulaC₁₉H₁₅NOS₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (15 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBjorklund, M., et al. 2006. Biochemistry 45, 2862.