505224 Sigma-AldrichInSolution™ Necrostatin-1 - Calbiochem
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InSolution™ Necrostatin-1 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: Necrosis Inhibitor II, 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one; 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, MTH-Trp, Methyl-thiohydantoin-tryptophan, Nec-1, Nec1, Necrosome Inhibitor I, RIP1 Inhibitor I, RIPK 1 Inhibitor I, Receptor-Interacting Protein 1 Inhibitor I
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Übersicht
| Replacement Information |
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Key Spec Table
| Empirical Formula |
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| C₁₃H₁₃N₃OS |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 5.05224.0001 |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect on RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). |
| Catalogue Number | 505224 |
| Brand Family | Calbiochem® |
| Synonyms | Necrosis Inhibitor II, 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one; 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, MTH-Trp, Methyl-thiohydantoin-tryptophan, Nec-1, Nec1, Necrosome Inhibitor I, RIP1 Inhibitor I, RIPK 1 Inhibitor I, Receptor-Interacting Protein 1 Inhibitor I |
| Product Information | |
|---|---|
| Form | Liquid |
| Formulation | A 25 mM (10 mg/1.54 ml) sterile-filtered solution of Necrostatin-1 (Cat. No. 480065) in DMSO. |
| Hill Formula | C₁₃H₁₃N₃OS |
| Chemical formula | C₁₃H₁₃N₃OS |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Purity | ≥99% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5.05224.0001 | 04055977263473 |
Documentation
InSolution™ Necrostatin-1 - Calbiochem SDB
| Titel |
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Literatur
| Übersicht |
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| Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192. Degterev, A., et al. 2012. Cell Death Differ. 20, 366. Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320. Takahashi, N., et al. 2012. Cell Death Dis. 3, e437. Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313. Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112. Muller, A.J., et al. 2005. Nat. Med. 11, 312. Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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