Millipore Sigma Vibrant Logo

500583 InSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem

A 25 mM solution of (+)-Brefeldin A in DMSO.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein

Primary Target: ADP-ribosylation factor (ARF)
View Products on Sigmaaldrich.com
500583
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
20350-15-6C₁₆H₂₄O₄

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
5.00583.0001
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Glasflasche 2 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      Description
      Catalogue Number500583
      Brand Family Calbiochem®
      Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein
      References
      ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.
      Product Information
      CAS number20350-15-6
      FormLiquid
      FormulationA 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO.
      Hill FormulaC₁₆H₂₄O₄
      Chemical formulaC₁₆H₂₄O₄
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetADP-ribosylation factor (ARF)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.00583.0001 04055977244984

      Documentation

      InSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-July-2014 JSW
      Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein
      DescriptionSpecifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange.
      FormLiquid
      FormulationA 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number20350-15-6
      Chemical formulaC₁₆H₂₄O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use.
      Toxicity Irritant
      ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.