412511 Sigma-AldrichIRE1 Inhibitor II - CAS 1093118-73-0 - Calbiochem
The IRE1 Inhibitor II controls the biological activity of IRE1.
More>> The IRE1 Inhibitor II controls the biological activity of IRE1. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: ER-to-Nucleus Signaling 1 Inhibitor II, Inositol-Requiring Protein 1 Inhibitor II, 3ʹ-Formyl-4ʹ-hydroxy-5ʹ-methoxybiphenyl-3-carboxamide
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1093118-73-0 | C₁₅H₁₃NO₄ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 412511-25MG |
|
Glasflasche | 25 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable salicylaldehyde compound that is shown to inhibit ER stress-induced Xbp1 mRNA splicing (100% inhibition by ≤25 µM in Tunicamycin-treated U373 cultures) in a reversible manner, presumably due to IRE1 inhibition via the same mechanism as 4µ8C (Cat. No. 412512) and STF083010 (Cat. No. 412510). IRE1 inhibition is shown to initiate signaling events leading to increased CRADD/RAIDD protein level (36 hrs post IRE1 inhibition in U373 cells), an important adaptor protein for caspase-2-mediated apoptosis response. Also shown to synergize with Maraba oncolytic therapy in mice (250 mg/kg/12 h via i.p. for 6 days before viral therapy) bearing Ovcar-4 or EMT6 in vivo. |
| Catalogue Number | 412511 |
| Brand Family | Calbiochem® |
| Synonyms | ER-to-Nucleus Signaling 1 Inhibitor II, Inositol-Requiring Protein 1 Inhibitor II, 3ʹ-Formyl-4ʹ-hydroxy-5ʹ-methoxybiphenyl-3-carboxamide |
| References | |
|---|---|
| References | Mahoney, D.J., et al. 2011. Cancer Cell 20, 443. |
| Product Information | |
|---|---|
| CAS number | 1093118-73-0 |
| Form | Tan solid |
| Hill Formula | C₁₅H₁₃NO₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | IRE1 |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 412511-25MG | 04055977188172 |
Documentation
IRE1 Inhibitor II - CAS 1093118-73-0 - Calbiochem SDB
| Titel |
|---|
IRE1 Inhibitor II - CAS 1093118-73-0 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 412511 |
Literatur
| Übersicht |
|---|
| Mahoney, D.J., et al. 2011. Cancer Cell 20, 443. |
| Datenblatt | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|