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401006 Hypoestoxide, Hypoestes rosea - Calbiochem

A naturally occurring, cell-permeable diterpene with anti-inflammatory properties.

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₂H₃₂O₅
      Description
      OverviewA naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells, thereby preventing NF-κB activation. Also inhibits the production of nitric oxide by IL-1β or IL-17 stimulated normal human chondrocytes. Reported to neither affect the synthesis of prostaglandin nor inhibit the activities of JNK and p38MAPK.
      Catalogue Number401006
      Brand Family Calbiochem®
      References
      ReferencesPulai, J.I., et al. 2005. J. Immunol. 174, 5781.
      Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
      Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₃₂O₅
      Chemical formulaC₂₂H₃₂O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIKB Kinase
      Primary Target IC<sub>50</sub>24 µM against IκB kinase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      401006 0

      Documentation

      Hypoestoxide, Hypoestes rosea - Calbiochem Analysenzertifikate

      TitelChargennummer
      401006

      Literatur

      Übersicht
      Pulai, J.I., et al. 2005. J. Immunol. 174, 5781.
      Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
      Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      DescriptionA naturally occurring, cell-permeable diterpene with anti-inflammatory properties. Acts as a selective and direct inhibitor of IκB kinase (IC50 = 24 µM) in TNF-α stimulated HeLa cells thereby prevents NF-κB activation. Also inhibits the production of nitric oxide in IL-1β or IL-17 stimulated normal human chondrocytes. Does not inhibit the activities of JNK and p38MAPK. Reported to be effective against murine blood and liver stages of malarial parasites. Inhibits VEGF-induced cell proliferation in vitro (IC50 = 28.6 µM) and bFGF-induced angiogenesis in the chick chorioallantoic membrane (IC50 = 10 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₃₂O₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (3 mg/ml) (slight warming may be required) or Ethanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 weeks at -20°C. Stock solutions in ethanol are stable for up to 2 months at -20°C.
      Toxicity Harmful
      ReferencesPulai, J.I., et al. 2005. J. Immunol. 174, 5781.
      Ojo-Amaize, E. A., et al. 2002. Cancer Res. 62, 4007.
      Ojo-Amaize, E.A., et al. 2001. Cell Immunol. 209, 149.