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373277 Hh Signaling Antagonist XI, MRT-14 - Calbiochem

The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

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Synonyme: N-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₄H₂₃N₃O₆
      Description
      OverviewA cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 & 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).
      Catalogue Number373277
      Brand Family Calbiochem®
      SynonymsN-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII
      References
      ReferencesManetti, F., et al. 2010. Mol. Pharmacol. 78, 658.
      Product Information
      FormWhite powder
      Hill FormulaC₂₄H₂₃N₃O₆
      Chemical formulaC₂₄H₂₃N₃O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      373277 0

      Documentation

      Hh Signaling Antagonist XI, MRT-14 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Hh Signaling Antagonist XI, MRT-14 - Calbiochem Analysenzertifikate

      TitelChargennummer
      373277

      Literatur

      Übersicht
      Manetti, F., et al. 2010. Mol. Pharmacol. 78, 658.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-October-2012 JSW
      SynonymsN-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII
      DescriptionA cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 and 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₃N₃O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesManetti, F., et al. 2010. Mol. Pharmacol. 78, 658.