373260 Sigma-AldrichHeat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem
Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.
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Synonyme: KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 218924-25-5 | C₁₃H₁₁NO₄ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 373260-5MG |
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Glasflasche | 5 mg |
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| Description | |
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| Overview | A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK. |
| Catalogue Number | 373260 |
| Brand Family | Calbiochem® |
| Synonyms | KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I |
| References | |
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| References | Koishi, M., et al. 2001. Clin. Cancer Res. 7, 215. Yokota, S., et al. 2000. Cancer Res. 60, 2942. |
| Product Information | |
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| CAS number | 218924-25-5 |
| ATP Competitive | N |
| Form | White to light yellow powder |
| Hill Formula | C₁₃H₁₁NO₄ |
| Chemical formula | C₁₃H₁₁NO₄ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Hsp70 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
| S Phrase | S: 36 Wear suitable protective clothing. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 373260-5MG | 04055977191004 |
Documentation
Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem SDB
| Titel |
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Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 373260 |
Literatur
| Übersicht |
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| Koishi, M., et al. 2001. Clin. Cancer Res. 7, 215. Yokota, S., et al. 2000. Cancer Res. 60, 2942. |