505276 Sigma-AldrichHSP70 Activator II, YM-08 - CAS 1427472-76-1 - Calbiochem
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Primary Target:
HSP70
SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: YM08, YM8, (2Z,5E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-2-(pyridin-2-ylmethylene)thiazolidin-4-one, Heat Shock 70 kDa Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08
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Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
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| 1427472-76-1 | C₁₉H₁₇N₃OS₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 5.05276.0001 |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | A cell-permeable, neutrally charged, pyridinium-to-pyridine substituted YM-01 (Cat. No. 500615) and MKT-077 structural analog that exhibits higher HSP70-binding affinity, but reduced tau degradation-promoting potency in cultures (% degradation of p-tau/total tau = 42/64, 88/89, and 81/80 in HeLaC3 with 30 µM YM-08, MKT-077, or YM-01, respectively) and weaker anti-cancer activity (IC50 against MDA-MB-231/MCF10A/MCF7 in µM = 1.4/3.0/2,2/MKT-077, 2.0/3.3/5.2/YM-01, and 8.5/7.8/10.5/YM-08 in 72 h). |
| Catalogue Number | 505276 |
| Brand Family | Calbiochem® |
| Synonyms | YM08, YM8, (2Z,5E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-2-(pyridin-2-ylmethylene)thiazolidin-4-one, Heat Shock 70 kDa Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08 |
| References | |
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| References | Miyata, Y., et al. 2013. ACS Chem. Neurosci. 4, 930. |
| Product Information | |
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| CAS number | 1427472-76-1 |
| Form | Orange solid |
| Hill Formula | C₁₉H₁₇N₃OS₂ |
| Chemical formula | C₁₉H₁₇N₃OS₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | HSP70 |
| Primary Target IC<sub>50</sub> | 0.6uM |
| Purity | ≥99% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5.05276.0001 | 04055977263534 |
Documentation
HSP70 Activator II, YM-08 - CAS 1427472-76-1 - Calbiochem SDB
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Literatur
| Übersicht |
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| Miyata, Y., et al. 2013. ACS Chem. Neurosci. 4, 930. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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