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400089 HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem

The HIF-1α/2α Inhibitor IV, FM19G11, also referenced under CAS 329932-55-0, controls the biological activity of HIF-1α/2α. This small molecule/inhibitor is primarily used for Cell Structure applications.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate, 2-(4-Methylphenyl)-2-oxoethyl-3-((2,4-dinitrobenzoyl)amino)benzoate, HIF Inhibitor IV

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      329932-55-0C₂₃H₁₇N₃O₈
      Description
      Overview

      This product has been discontinued.



      A cell-permeable benzamido-benzoate compound that is shown to prevent hypoxia-induced increase in HIF-1α and HIF-2α protein levels in HeLa cultures, resulting in a blockage of HIF Responsive Element- (HRE) mediated transcription activity under hypoxia (1% O2) condition (IC50 = 80 nM in HeLa-based luciferase reporter assays). FM19G11 treatment is also reported to decrease HIF-2α-dependent Oct4 and Sox2 mRNA accumulation under hypoxia condition in a dose-dependent manner in both rat epSPC (ependymal stem/progenitor cell) and human hESC (embryonic stem cell) cultures, resulting in a 50% drop of cellular Oct4 and Sox2 protein level after 48 hours with 500 nM FM19G11.
      Catalogue Number400089
      Brand Family Calbiochem®
      Synonyms2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate, 2-(4-Methylphenyl)-2-oxoethyl-3-((2,4-dinitrobenzoyl)amino)benzoate, HIF Inhibitor IV
      References
      ReferencesMoreno-Manzano, V., et al. 2009. J. Biol. Chem. 284, 36047.
      Product Information
      CAS number329932-55-0
      FormPale amber solid
      Hill FormulaC₂₃H₁₇N₃O₈
      Chemical formulaC₂₃H₁₇N₃O₈
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUse only fresh DMSO for reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      400089 0

      Documentation

      HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      HIF-1α/2α Inhibitor IV, FM19G11 - CAS 329932-55-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      400089

      Literatur

      Übersicht
      Moreno-Manzano, V., et al. 2009. J. Biol. Chem. 284, 36047.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate, 2-(4-Methylphenyl)-2-oxoethyl-3-((2,4-dinitrobenzoyl)amino)benzoate, HIF Inhibitor IV
      DescriptionA cell-permeable benzamido-benzoate compound that is shown to prevent hypoxia-induced increase in HIF-1α and HIF-2α protein levels in HeLa cultures, resulting in a blockage of HIF Responsive Element- (HRE) mediated transcription activity under hypoxia (1% O2) condition (IC50 = 80 nM in HeLa-based luciferase reporter assays). FM19G11 treatment is also reported to decrease HIF-2α-dependent Oct4 and Sox2 mRNA accumulation under hypoxia condition in a dose-dependent manner in both rat epSPC (ependymal stem/progenitor cell) and human hESC (embryonic stem cell) cultures, resulting in a 50% drop of cellular Oct4 and Sox2 protein level after 48 h with 500 nM FM19G11.
      FormPale amber solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number329932-55-0
      Chemical formulaC₂₃H₁₇N₃O₈
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsUse only fresh DMSO for reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMoreno-Manzano, V., et al. 2009. J. Biol. Chem. 284, 36047.