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371545 Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP.

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Synonyme: GTPγ-S, 4Li

Primary Target: G-protein-activating GTP analog
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      94825-44-2C₁₀H₁₂N₅O₁₃P₃S . 4Li
      Description
      OverviewG-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.
      Catalogue Number371545
      Brand Family Calbiochem®
      SynonymsGTPγ-S, 4Li
      References
      ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
      Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
      Hess, S.D., et al. 1993. Science 259, 1169.
      Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
      McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
      Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
      Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
      Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
      Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
      Product Information
      CAS number94825-44-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
      Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetG-protein-activating GTP analog
      Purity≥85% by HPLC.
      Physicochemical Information
      Cell permeableN
      ContaminantsGDP: ≤12%
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      371545 0

      Documentation

      Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      371545

      Literatur

      Übersicht
      Iino, S., et al. 2000. FEBS Lett. 479, 46.
      Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
      Hess, S.D., et al. 1993. Science 259, 1169.
      Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
      McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
      Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
      Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
      Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
      Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2009 JSW
      SynonymsGTPγ-S, 4Li
      DescriptionG-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P3 formation in membranes.
      FormWhite solid
      CAS number94825-44-2
      Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
      Structure formulaStructure formula
      Purity≥85% by HPLC.
      ContaminantsGDP: ≤12%
      SolubilityH₂O (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
      Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
      Hess, S.D., et al. 1993. Science 259, 1169.
      Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
      McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
      Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
      Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
      Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
      Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.