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508410 Glycogen Phosphorylase Inhibitor II, KB228 - CAS 1595277-35-2 - Calbiochem

A mixed type inhibitor of muscle glycogen phosphorylase (Ki = 930 nM).

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: KB-228

Primary Target: Glycogen Phosphorylase
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508410
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
1595277-35-2C₁₆H₂₂N₂O₇

Preis & Verfügbarkeit

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5.08410.0001
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      Description
      OverviewA glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508410
      Brand Family Calbiochem®
      SynonymsKB-228
      References
      ReferencesNagy, L., et al. 2013. PLoS One. 8, e69420.
      Product Information
      CAS number1595277-35-2
      FormWhite powder
      Hill FormulaC₁₆H₂₂N₂O₇
      Chemical formulaC₁₆H₂₂N₂O₇
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGlycogen Phosphorylase
      Primary Target K<sub>i</sub>930 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.08410.0001 04055977261943

      Documentation

      Glycogen Phosphorylase Inhibitor II, KB228 - CAS 1595277-35-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Nagy, L., et al. 2013. PLoS One. 8, e69420.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-July-2014 JSW
      SynonymsKB-228
      DescriptionA glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1595277-35-2
      Chemical formulaC₁₆H₂₂N₂O₇
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNagy, L., et al. 2013. PLoS One. 8, e69420.