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361570 GSK-3β Inhibitor XXVII - Calbiochem

GSK-3β Inhibitor XXVII, CAS 486424-21-9, is a cell-permeable, highly potent, reversible, and ATP-competitive inhibitor of GSK-3β (Ki = 4.9 nM).

GSK-3β Inhibitor XXVII - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl

Primary Target: GSK-3β
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₁H₂₃N₇O₃S• 2.5 HCl•5H₂O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable pyridinylpyrazinecarboxamide compound that acts as a highly potent, reversible, and ATP-competitive inhibitor of GSK-3β (Ki = 4.9 nM) with ~110-fold greater selectivity over Cdk2 (Ki = 540 nM). Shows only a trivial effect on the activities of 26-related kinases at much higher doses. Blocks GSK-3β-mediated phosphorylation of Ser396 in stably transfected 3T3 fibroblasts expressing four-repeat tau protein (IC50 = 76 nM). Readily crosses blood-brain barrier and exhibits desirable bioavailability and aqueous solubility.
      Catalogue Number361570
      Brand Family Calbiochem®
      Synonyms3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl
      References
      ReferencesBerg. S., et al. 2012. J. Med. Chem. 55, 9107.
      Product Information
      FormYellow powder
      Hill FormulaC₂₁H₂₃N₇O₃S• 2.5 HCl•5H₂O
      Chemical formulaC₂₁H₂₃N₇O₃S• 2.5 HCl•5H₂O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGSK-3β Inhibitor XXVII, CAS 486424-21-9, is a cell-permeable, highly potent, reversible, and ATP-competitive inhibitor of GSK-3β (Ki = 4.9 nM).
      Biological Information
      Primary TargetGSK-3β
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      361570 0

      Documentation

      GSK-3β Inhibitor XXVII - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      GSK-3β Inhibitor XXVII - Calbiochem Analysenzertifikate

      TitelChargennummer
      361570

      Literatur

      Übersicht
      Berg. S., et al. 2012. J. Med. Chem. 55, 9107.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2013 JSW
      Synonyms3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl
      DescriptionA cell-permeable pyridinylpyrazinecarboxamide compound that acts as a highly potent, reversible, and ATP-competitive inhibitor of GSK-3β (Ki = 4.9 nM) with ~110-fold greater selectivity over Cdk2 (Ki = 540 nM). Shows only a trivial effect on the activities of 26-related kinases at much higher doses. Blocks GSK-3β-mediated phosphorylation of Ser396 in stably transfected 3T3 fibroblasts expressing four-repeat tau protein (IC50 = 76 nM). Readily crosses blood-brain barrier and exhibits desirable bioavailability and aqueous solubility.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₂₃N₇O₃S• 2.5 HCl•5H₂O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBerg. S., et al. 2012. J. Med. Chem. 55, 9107.