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361564 GSK-3 Inhibitor XXIII, 3F8 - CAS 159109-11-2 - Calbiochem

The GSK-3 Inhibitor XXIII, 3F8, also referenced under CAS 159109-11-2, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: 5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      159109-11-2C₁₅H₁₄N₂O₄
      Description
      OverviewA cell-permeable maleimide compound that acts as a potent, reversible, and ATP-competitive inhibitor against GSK-3β (Cat. No. 361524) activity (IC50 = 34, 67 and 304 nM in the presence of 10, 30 and 100 µM ATP, respectively), while exhibiting much reduced activity against Cdk2/A, KDR (71% and 53% inhibition, respectively, at 5µM inhibitor concentration), and a panel of 19 other kinases (IC50 >5 µM). Shown to potently activate cellular Wnt pathway and increase β-catenin-dependent reporter transcription (by 15-fold at 4 µM) in 293T cultures in vitro and, when applied at or prior to the shield stage of embryo, interfere with zebrafish forebrain development in vivo.
      Catalogue Number361564
      Brand Family Calbiochem®
      Synonyms5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione
      References
      ReferencesZou, H., et al. 2010. J. Med. Chem. 53, 994.
      Zhong, H., et al. 2009. Mol. BioSyst. 5, 1356.
      Product Information
      CAS number159109-11-2
      FormYellow solid
      Hill FormulaC₁₅H₁₄N₂O₄
      Chemical formulaC₁₅H₁₄N₂O₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      361564 0

      Documentation

      GSK-3 Inhibitor XXIII, 3F8 - CAS 159109-11-2 - Calbiochem Analysenzertifikate

      TitelChargennummer
      361564

      Literatur

      Übersicht
      Zou, H., et al. 2010. J. Med. Chem. 53, 994.
      Zhong, H., et al. 2009. Mol. BioSyst. 5, 1356.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione
      DescriptionA cell-permeable maleimide compound that acts as a potent, reversible, and ATP-competitive inhibitor against GSK-3β (Cat. No. 361524) activity (IC50 = 34, 67 and 304 nM in the presence of 10, 30 and 100 µM ATP, respectively), while exhibiting much reduced activity against Cdk2/A, KDR (71% and 53% inhibition, respectively, at 5µM inhibitor concentration), and a panel of 19 other kinases (IC50 >5 µM). Shown to potently activate cellular Wnt pathway and increase β-catenin-dependent reporter transcription (by 15-fold at 4 µM) in 293T cultures in vitro and, when applied at or prior to the shield stage of embryo, interfere with zebrafish forebrain development in vivo.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number159109-11-2
      Chemical formulaC₁₅H₁₄N₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesZou, H., et al. 2010. J. Med. Chem. 53, 994.
      Zhong, H., et al. 2009. Mol. BioSyst. 5, 1356.