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361558 GSK-3 Inhibitor XV - Calbiochem

GSK-3 Inhibitor XV, is a cell-permeable, reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively).

GSK-3 Inhibitor XV - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Primary Target: GSK-3
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₅H₁₄BrN₃O₆Ru
      Description
      Overview

      This product has been discontinued.



      The racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage.
      Catalogue Number361558
      Brand Family Calbiochem®
      References
      ReferencesAtilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.
      Product Information
      ATP CompetitiveY
      DeclarationSold for research purposes only, pursuant to an agreement with University of Pennsylvania. Sold under license of U.S. Patent 7,488,817.
      FormPurple solid
      Hill FormulaC₂₅H₁₄BrN₃O₆Ru
      Chemical formulaC₂₅H₁₄BrN₃O₆Ru
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGSK-3 Inhibitor XV, is a cell-permeable, reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively).
      Biological Information
      Primary TargetGSK-3
      Primary Target IC<sub>50</sub>0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      361558 0

      Documentation

      GSK-3 Inhibitor XV - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      GSK-3 Inhibitor XV - Calbiochem Analysenzertifikate

      TitelChargennummer
      361558

      Literatur

      Übersicht
      Atilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-February-2008 JSW
      DescriptionThe racemic mixture of a cell-permeable pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a reversible, ATP-competitive, and highly potent inhibitor of GSK-3 (IC50 = 0.4 and 0.6 nM for GSK-3α and GSK-3β, respectively) with ∼5-fold selectivity over PIM-1 kinase (IC50 = 3 nM). Studies using isolated enantiomers have shown that the (R)-enantiomer is GSK-3-selective (IC50 = 0.35, 0.55, and 35 nM for GSK-3α GSK-3β, and Pim-1, respectively) and interferes with normal zebrafish embryo development (1 µM), while the (S)-enantiomer is Pim-1-selective (IC50 = 80, 90, and 3 nM for GSK-3α GSK-3β, and Pim-1, respectively) and exhibits no effect in embryo development at the same dosage.
      FormPurple solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₁₄BrN₃O₆Ru
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (6 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAtilla-Gokcumen, G.E., et al. 2006. ChemBioChem 7, 1443.