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508120 GR113808 - CAS 144625-51-4 - Calbiochem

GR113808 - CAS 144625-51-4 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 5-HT₄ Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808

Primary Target: 5-HT₄
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      144625-51-4C₁₉H₂₇N₃O₄S
      Description
      Overview

      This product has been discontinued.



      A potent and selective antagonist of the serotonin 5-HT4 receptor (pki = 9.3-10.3). GR113808 is commonly used in brain and peripheral in vitro and in vivo in striatum studies (Guinea pig IC50 = 113 nM, rat brain membrane Kd = 0.4-1 nM) and in cAMP response in CHO and C6 glial cells (EC50 = 79-81 nM).
      Catalogue Number508120
      Brand Family Calbiochem®
      Synonyms5-HT₄ Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808
      References
      ReferencesJohnson, D. E. et al. 2012. J. Pharmacol. Exp. Ther. 112, 681.
      Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther. 283, 1000.
      Gale, J. D. et al. 1994. Br. J. Pharmacol. 111, 332.
      Product Information
      CAS number144625-51-4
      FormOff-white solid
      Hill FormulaC₁₉H₂₇N₃O₄S
      Chemical formulaC₁₉H₂₇N₃O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT₄
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      508120 0

      Documentation

      GR113808 - CAS 144625-51-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Johnson, D. E. et al. 2012. J. Pharmacol. Exp. Ther. 112, 681.
      Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther. 283, 1000.
      Gale, J. D. et al. 1994. Br. J. Pharmacol. 111, 332.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-October-2013 JSW
      Synonyms5-HT₄ Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808
      DescriptionA potent and selective antagonist of the serotonin 5-HT4 receptor (pki = 9.3-10.3). GR113808 is commonly used in brain and peripheral in vitro and in vivo in striatum studies (Guinea pig IC50 = 113 nM, rat brain membrane Kd = 0.4-1 nM) and in cAMP response in CHO and C6 glial cells (EC50 = 79-81 nM).
      FormOff-white solid
      CAS number144625-51-4
      Chemical formulaC₁₉H₂₇N₃O₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM) or Ethanol (10 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJohnson, D. E. et al. 2012. J. Pharmacol. Exp. Ther. 112, 681.
      Mine, Y. et al. 1997. J. Pharmacol. Exp. Ther. 283, 1000.
      Gale, J. D. et al. 1994. Br. J. Pharmacol. 111, 332.