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371822 GPR120 Agonist III - Calbiochem

The GPR120 Agonist III controls the biological activity of GPR120. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

GPR120 Agonist III - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 3-(4-((4-Fluoro-4ʹ-methyl-(1,1ʹ-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid

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      Übersicht

      Replacement Information
      Description
      OverviewA membrane-permeant biphenyl-methoxy-phenylpropanoate compound that acts as an active-site targeting, selective, potent agonist of G-protein coupled receptor 120/GPR120 (EC50 of β-arrestin 2 recruitment = 17 nM and 44 nM for mGPR120 and hGPR120, respectively; EC50 of Ca++ mobilization = 96 nM for hGPR120). Exhibits much reduced potency toward free fatty acid receptor 1/FFA1/GPR40 (EC50 of β-arrestin 2 recruitment = 64.6 µM) and no activity toward short chain FFA receptors FFA2/GPR43 and FFA3/GPR41.
      Catalogue Number371822
      Brand Family Calbiochem®
      Synonyms3-(4-((4-Fluoro-4ʹ-methyl-(1,1ʹ-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid
      References
      ReferencesShimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.
      Product Information
      FormWhite powder
      Hill FormulaC₂₃H₂₁FO₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetG-protein coupled receptor 120
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      371822 0

      Documentation

      GPR120 Agonist III - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      GPR120 Agonist III - Calbiochem Analysenzertifikate

      TitelChargennummer
      371822

      Literatur

      Übersicht
      Shimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-October-2012 JSW
      Synonyms3-(4-((4-Fluoro-4ʹ-methyl-(1,1ʹ-biphenyl)-2-yl)methoxy)-phenyl)propanoic acid
      DescriptionA membrane-permeant biphenyl-methoxy-phenylpropanoate compound that acts as an active-site targeting, selective, potent agonist of G-protein coupled receptor 120/GPR120 (EC50 of β-arrestin 2 recruitment = 17 nM and 44 nM for mGPR120 and hGPR120, respectively; EC50 of Ca++ mobilization = 96 nM for hGPR120). Exhibits much reduced potency toward free fatty acid receptor 1/FFA1/GPR40 (EC50 of β-arrestin 2 recruitment = 64.6 µM) and no activity toward short chain FFA receptors FFA2/GPR43 and FFA3/GPR41.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesShimpukade, B., et al. 2012. J. Med. Chem. 55, 4511.