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365252 Gö 7874, Hydrochloride - CAS 287935-76-6 - Calbiochem

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC₅₀ = 4 nM for rat brain PKC).

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: MLCK Inhibitor III

Primary Target: PKC
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      287935-76-6C₂₇H₂₆N₄O₄ · HCl
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC). Inhibits protein kinase A (IC50 = 510 nM), protein kinase G (IC50 = 4.8 µM), and myosin light chain kinase (IC50 = 120 nM) at much higher concentrations.
      Catalogue Number365252
      Brand Family Calbiochem®
      SynonymsMLCK Inhibitor III
      References
      ReferencesKleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett. 5, 55.
      Product Information
      CAS number287935-76-6
      ATP CompetitiveY
      FormAmber solid
      Hill FormulaC₂₇H₂₆N₄O₄ · HCl
      Chemical formulaC₂₇H₂₆N₄O₄ · HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>4 nM against rat brain PKC
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      365252 0

      Documentation

      Gö 7874, Hydrochloride - CAS 287935-76-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Gö 7874, Hydrochloride - CAS 287935-76-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      365252

      Literatur

      Übersicht
      Kleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett. 5, 55.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsMLCK Inhibitor III
      DescriptionA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of rat brain protein kinase C (IC50 = 4 nM) versus myosin light chain kinase (IC50 = 0.12 µM), protein kinase A (IC50 = 510 nM), and protein kinase G (IC50 = 4.8 µM).
      FormAmber solid
      CAS number287935-76-6
      Chemical formulaC₂₇H₂₆N₄O₄ · HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett. 5, 55.