Millipore Sigma Vibrant Logo

344930 Furin Inhibitor I - Calbiochem

Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

Furin Inhibitor I - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Decanoyl-RVKR-CMK

Primary Target: viral glycoproteins
View Products on Sigmaaldrich.com
344930
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

Empirical Formula
C₃₄H₆₆ClN₁₁O₅

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
344930-150MG
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Kst.-Ampulle 150 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      344930-1MG
      Verfügbarkeit wird abgerufen...
      —
      Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
      Lieferbar 
      Produkt wurde eingestellt
      Begrenzter Lagerbestand
      Bestätigung der Verfügbarkeit erforderlich
        Restmenge: Angebot folgt
          Restmenge: Angebot folgt
          Bitte erfragen
          Kontakt zum Kundenservice
          Contact Customer Service

          		 Kst.-Ampulle 1 mg
          Preis wird abgerufen...
          Preis nicht abrufbar
          Die Mindestmenge muss ein Vielfaches sein von
          Maximum Quantity is
          Bei Bestätigung Weitere Informationen
          Sie haben () gespart
           
          —
          Bitte erfragen
          		 —
          Description
          OverviewA peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
          Catalogue Number344930
          Brand Family Calbiochem®
          SynonymsDecanoyl-RVKR-CMK
          References
          ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
          Product Information
          FormOff-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₃₄H₆₆ClN₁₁O₅
          Chemical formulaC₃₄H₆₆ClN₁₁O₅
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetviral glycoproteins
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Bestellnummer GTIN
          344930-150MG 04055977194388
          344930-1MG 04055977194371

          Documentation

          Furin Inhibitor I - Calbiochem SDB

          Titel

          Sicherheitsdatenblatt (SDB) 

          Furin Inhibitor I - Calbiochem Analysenzertifikate

          TitelChargennummer
          344930

          Literatur

          Übersicht
          Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
          Datenblatt

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2008 RFH
          SynonymsDecanoyl-RVKR-CMK
          DescriptionA peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
          FormOff-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₃₄H₆₆ClN₁₁O₅
          Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO or Methanol (1 mg/ml)
          Storage Protect from moisture
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.