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344280 Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM).

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: FST, Phosphotrienin

Primary Target: PP2a
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      87860-39-7C₁₉H₂₆O₉PNa
      Description
      Overview

      This product has been discontinued.



      An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC50 = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC50 = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.
      Catalogue Number344280
      Brand Family Calbiochem®
      SynonymsFST, Phosphotrienin
      References
      ReferencesCheng, A., et al. 1998. Cancer Res. 58, 3611.
      Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
      Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.
      Product Information
      CAS number87860-39-7
      ATP CompetitiveN
      FormColorless solid
      Hill FormulaC₁₉H₂₆O₉PNa
      Chemical formulaC₁₉H₂₆O₉PNa
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPP2a
      Primary Target IC<sub>50</sub>3.2 nM, 131 µM, against protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1), respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUQ0600000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      344280 0

      Documentation

      Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      344280

      Literatur

      Übersicht
      Cheng, A., et al. 1998. Cancer Res. 58, 3611.
      Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
      Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.

      Broschüre

      Titel
      Protein Phosphatases Technical Bulletin

      Literaturstellen

      Titel
    • Ramesh M. Ray, Sujoy bhattacharya and Leonard R. Johnson. (2005) Protein phosphatase 2A (PP2A) regulates apoptosis in IEC-6 cells. Journal of Biological Chemistry 280, 31091-31100.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2008 RFH
      SynonymsFST, Phosphotrienin
      DescriptionAntitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC50 = 3.2 nM). Also inhibits protein phosphatase 1 (PP1) at higher concentrations (IC50 = 131 µM), but has no effect on protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.
      FormColorless solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number87860-39-7
      RTECSUQ0600000
      Chemical formulaC₁₉H₂₆O₉PNa
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol (10 mg/ml), Methanol (10 mg/ml), or H₂O (50 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesCheng, A., et al. 1998. Cancer Res. 58, 3611.
      Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
      Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.
      Citation
    • Ramesh M. Ray, Sujoy bhattacharya and Leonard R. Johnson. (2005) Protein phosphatase 2A (PP2A) regulates apoptosis in IEC-6 cells. Journal of Biological Chemistry 280, 31091-31100.
      		•