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344085 Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem

A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM).

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Synonyme: Concanamycin A

Primary Target: Vacuolar-type H+-ATPase
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      80890-47-7C₄₆H₇₅NO₁₄
      Description
      OverviewA highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.
      Catalogue Number344085
      Brand Family Calbiochem®
      SynonymsConcanamycin A
      References
      ReferencesKane, M.D., et al. 1999. J. Neurochem. 72, 1939.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
      Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
      Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.
      Product Information
      CAS number80890-47-7
      ATP CompetitiveN
      FormLyophilized solid
      Hill FormulaC₄₆H₇₅NO₁₄
      Chemical formulaC₄₆H₇₅NO₁₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVacuolar-type H+-ATPase
      Primary Target K<sub>i</sub>20 pM against vacuolar-type H+-ATPase
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLP5970000
      Safety Information
      R PhraseR: 28-37

      Very toxic if swallowed.
      Irritating to respiratory system.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      344085 0

      Documentation

      Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      344085

      Literatur

      Übersicht
      Kane, M.D., et al. 1999. J. Neurochem. 72, 1939.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
      Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
      Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2008 RFH
      SynonymsConcanamycin A
      DescriptionA highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.
      FormLyophilized solid
      CAS number80890-47-7
      RTECSLP5970000
      Chemical formulaC₄₆H₇₅NO₁₄
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO. Further dilute with aqueous buffers just prior to use.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
      Toxicity Highly Toxic
      ReferencesKane, M.D., et al. 1999. J. Neurochem. 72, 1939.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
      Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
      Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.