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341598 Sigma-AldrichFibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem

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Analysenzertifikat
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Data Sheet

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341598

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Übersicht

Replacement Information

Key Spec Table

Empirical Formula
C₂₁H₁₄N₂Na₂O₉S₂

Description
Overview	This product has been discontinued. A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC₅₀ = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC₅₀ = 24.0 ±6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC₅₀ = 20.3 µM ±5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ±2 (FGF-2 + NSC37203).
Catalogue Number	341598
Brand Family	Calbiochem®

Description

Overview

This product has been discontinued.

A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC₅₀ = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC₅₀ = 24.0 ±6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC₅₀ = 20.3 µM ±5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ±2 (FGF-2 + NSC37203).

Catalogue Number

341598

Brand Family

Calbiochem®

References
References	Colombo, G., et al. 2010. J. Biol. Chem. 285, 8733.

Product Information
Form	Brown solid
Hill Formula	C₂₁H₁₄N₂Na₂O₉S₂
Chemical formula	C₂₁H₁₄N₂Na₂O₉S₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	>95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Bestellnummer	GTIN
341598	0

Documentation

Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem SDB

Titel
Sicherheitsdatenblatt (SDB)

Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem Analysenzertifikate

Titel	Chargennummer
341598	Chargen-Nr.

Literatur

Übersicht
Colombo, G., et al. 2010. J. Biol. Chem. 285, 8733.

Datenblatt

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-December-2010 RFH
Description	A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC₅₀ = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC₅₀ = 24.0 ± 6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC₅₀ = 20.3 µM ± 5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ± 2 (FGF-2 + NSC37203).
Form	Brown solid
Chemical formula	C₂₁H₁₄N₂Na₂O₉S₂
Structure formula
Purity	>95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Colombo, G., et al. 2010. J. Biol. Chem. 285, 8733.

Kategorien

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Angiogenesis Inhibitors > Angiogenesis Inhibitors

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