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344149 FPRL1 Agonist II, C43 - Calbiochem

FPRL1 Agonist II, C43 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1-(4-chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea, Formyl Peptide Receptor-Like 1 Agonist II, FPR2 Agonist II, ALX Agonist II

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      Übersicht

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      An orally available, stable, pyrazolone derivative that acts as a potent prototypic agonist of human formyl-peptide-like 1 receptor (hFPRL1; FPR2) (EC50 = 44 nM). Also shown to block polymorphonuclear neutrophil (PMN) migration in a dose-dependent manner, irrespective of the type of stimulant applied. Reported to act by activating extracellular loop I, while the downstream signaling effects are attributed to its loop II region. Does not affect several other protein targets studied, such as p38a, CXCR2, histamine receptor, and TRPV1 (~10 mM). Exhibit suitable pharmacokinetic properties, such as low clearance (126 ml/h/kg) and a half-life of ~2.78 hours. Shown to significantly reduce edema in mouse ear (~50 mg/kg) following oral administration.
      Catalogue Number344149
      Brand Family Calbiochem®
      Synonyms1-(4-chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea, Formyl Peptide Receptor-Like 1 Agonist II, FPR2 Agonist II, ALX Agonist II
      References
      ReferencesBena, S., et al. 2012, J Biol Chem 287, 24690.
      Burli, R. W, et al. 2006, Bioorg Med Chem Lett. 16, 3713.
      Product Information
      FormLight brown powder
      Hill FormulaC₂₀H₂₁ClN₄O₂
      Chemical formulaC₂₀H₂₁ClN₄O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥93% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      344149 0

      Documentation

      FPRL1 Agonist II, C43 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Bena, S., et al. 2012, J Biol Chem 287, 24690.
      Burli, R. W, et al. 2006, Bioorg Med Chem Lett. 16, 3713.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2013 JSW
      Synonyms1-(4-chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea, Formyl Peptide Receptor-Like 1 Agonist II, FPR2 Agonist II, ALX Agonist II
      DescriptionAn orally available, stable, pyrazolone derivative that acts as a potent prototypic agonist of human formyl-peptide-like 1 receptor (hFPRL1; FPR2) (EC50 = 44 nM). Also shown to block polymorphonuclear neutrophil (PMN) migration in a dose-dependent manner, irrespective of the type of stimulant applied. Reported to act by activating extracellular loop I, while the downstream signaling effects are attributed to its loop II region. Does not affect several other protein targets studied, such as p38a, CXCR2, histamine receptor, and TRPV1 (~10 mM). Exhibit suitable pharmacokinetic properties, such as low clearance (126 ml/h/kg) and a half-life of ~2.78 hours. Shown to significantly reduce edema in mouse ear (~50 mg/kg) following oral administration.
      FormLight brown powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₁ClN₄O₂
      Structure formulaStructure formula
      Purity≥93% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBena, S., et al. 2012, J Biol Chem 287, 24690.
      Burli, R. W, et al. 2006, Bioorg Med Chem Lett. 16, 3713.