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325001 Epothilone B, Synthetic

A structural analog of Epothilone A with similar biological properties.

Epothilone B, Synthetic: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: EpoB

Primary Target: P-glycoprotein-expressing multidrug resistant (MDR) cells
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      Übersicht

      Key Spec Table

      CAS #Empirical Formula
      152044-54-7C₂₇H₄₁NO₆S
      Description
      Overview

      This product has been discontinued.



      A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells).
      Catalogue Number325001
      Brand Family Calbiochem®
      SynonymsEpoB
      References
      ReferencesGiannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2904.
      Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
      Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
      Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
      Nicolaou, K.C., et al. 1997. Nature 387, 268.
      Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.
      Product Information
      CAS number152044-54-7
      ATP CompetitiveN
      DeclarationNot available for sale in Germany.
      FormWhite to off-white solid
      Hill FormulaC₂₇H₄₁NO₆S
      Chemical formulaC₂₇H₄₁NO₆S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetP-glycoprotein-expressing multidrug resistant (MDR) cells
      Primary Target IC<sub>50</sub>2 nM for MDR CCRF-CEM/VBL100 cells
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information
      R PhraseR: 23/24/25-37/38-41-46-60

      Toxic by inhalation, in contact with skin and if swallowed.
      Irritating to respiratory system and skin.
      Risk of serious damage to eyes.
      May cause heritable genetic damage.
      May impair fertility.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Global Trade Item Number
      Bestellnummer GTIN
      325001 0