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324768 Endostatin, Human, Recombinant, Pichia pastoris

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      Übersicht

      Replacement Information
      Description
      OverviewRecombinant, human endostatin expressed in Pichia pastoris. Endostatin is a ~20 kDa C-terminal fragment of collagen XVIII that acts as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to apoptosis in endothelial cells.
      Catalogue Number324768
      Brand Family Calbiochem®
      References
      ReferencesDixelius, J., et al. 2000. Blood 95, 3403. Boehm, T., et al. 1999. Yeast 15, 563. Dhanabal, M., et al. 1999. Biochem. Biophys. Res. Commun. 258, 345. Dhanabal, M., et al. 1999. J. Biol. Chem. 274, 11721. Moulton, K.S., et al. 1999. Circulation 99, 1726. OʹReilly, M.S., et al. 1997. Cell 88, 277.
      Product Information
      DeclarationSold under license of U.S. Patents 6,764,995, 6,746,865 and corresponding patents.
      FormLiquid
      FormulationIn 66 mM sodium phosphate, 59 mM NaCl, 17 mM citric acid, pH 6.2.
      Applications
      Biological Information
      Biological activity10 µg/ml endostatin will inhibit 50% tube formation in the presence of 10 ng/ml VEGF and 70% tube formation in the presence of 5 ng/ml bFGF
      Purity≥95% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsEndotoxin: ≤ 0.50 EU/mg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      324768 0

      Documentation

      Endostatin, Human, Recombinant, Pichia pastoris Analysenzertifikate

      TitelChargennummer
      324768

      Literatur

      Übersicht
      Dixelius, J., et al. 2000. Blood 95, 3403. Boehm, T., et al. 1999. Yeast 15, 563. Dhanabal, M., et al. 1999. Biochem. Biophys. Res. Commun. 258, 345. Dhanabal, M., et al. 1999. J. Biol. Chem. 274, 11721. Moulton, K.S., et al. 1999. Circulation 99, 1726. OʹReilly, M.S., et al. 1997. Cell 88, 277.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-October-2007 JSW
      DescriptionRecombinant, human endostatin expressed in Pichia pastoris. Endostatin is a ~20 kDa C-terminal fragment of collagen XVIII that acts as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to apoptosis in endothelial cells.
      FormLiquid
      FormulationIn 66 mM sodium phosphate, 59 mM NaCl, 17 mM citric acid, pH 6.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      Purity≥95% by HPLC
      ContaminantsEndotoxin: ≤ 0.50 EU/mg protein
      Biological activity10 µg/ml endostatin will inhibit 50% tube formation in the presence of 10 ng/ml VEGF and 70% tube formation in the presence of 5 ng/ml bFGF
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesDixelius, J., et al. 2000. Blood 95, 3403. Boehm, T., et al. 1999. Yeast 15, 563. Dhanabal, M., et al. 1999. Biochem. Biophys. Res. Commun. 258, 345. Dhanabal, M., et al. 1999. J. Biol. Chem. 274, 11721. Moulton, K.S., et al. 1999. Circulation 99, 1726. OʹReilly, M.S., et al. 1997. Cell 88, 277.