Millipore Sigma Vibrant Logo

504539 Eliprodil - CAS 119431-25-3 - Calbiochem

Eliprodil - CAS 119431-25-3 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX

Primary Target: NMDA receptors
View Products on Sigmaaldrich.com
504539
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
119431-25-3C₂₀H₂₃ClFNO

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
5.04539.0001
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Glasflasche 10 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      Description
      OverviewA negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, >100, and >100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for α1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain α receptors. Blocks neuronal voltage-gated Ca2+
      Catalogue Number504539
      Brand Family Calbiochem®
      Synonymsα-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX
      References
      ReferencesLengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
      Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
      Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
      Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.
      Product Information
      CAS number119431-25-3
      FormWhite solid
      Hill FormulaC₂₀H₂₃ClFNO
      Chemical formulaC₂₀H₂₃ClFNO
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>1, > 100, and > 100 →M for NR2B, NR2A, and NR2C, respectively.
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.04539.0001 04055977244878

      Documentation

      Eliprodil - CAS 119431-25-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Lengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
      Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
      Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
      Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonymsα-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX
      DescriptionA negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, > 100, and > 100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for ς1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain ς receptors. Blocks neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). A neuroprotective agent in acute ischemic stroke. Prolongs the QT interval in EKG.
      FormWhite solid
      CAS number119431-25-3
      Chemical formulaC₂₀H₂₃ClFNO
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (17 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
      Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
      Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
      Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.