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324841 EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor - CAS 1135256-66-4 - Calbiochem

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Synonyme: 1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      1135256-66-4C₁₈H₁₈Cl₂N₆O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.
      Catalogue Number324841
      Brand Family Calbiochem®
      Synonyms1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII
      References
      ReferencesHamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
      Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.
      Product Information
      CAS number1135256-66-4
      FormPale yellow solid
      Hill FormulaC₁₈H₁₈Cl₂N₆O
      Chemical formulaC₁₈H₁₈Cl₂N₆O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥ 97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-37-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      324841 0

      Documentation

      EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor - CAS 1135256-66-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      324841

      Literatur

      Übersicht
      Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
      Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-May-2011 RFH
      Synonyms1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD-089828, PDGFR Tyrosine Kinase Inhibitor XIII
      DescriptionA cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Src, and EGFR (IC50 = 0.15, 0.18, 1.76, and 5.47 µM, respectively), while exhibiting little activity against InsR, PKC, or CDK4/Cyclin D1 (IC50 >50 µM). The inhibition is shown to be ATP-competitive in the case of FGFR-1, PDGFR-β, and EGFR, but noncompetitive in the case of c-Src.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1135256-66-4
      Chemical formulaC₁₈H₁₈Cl₂N₆O
      Structure formulaStructure formula
      Purity≥ 97% by HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
      Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.