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324378 Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem

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Synonyme: 25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid

Primary Target: Glutamate kainate receptor
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      14277-97-5C₁₅H₂₁NO₆
      Description
      Overview

      This product has been discontinued.



      A heat-stable neurotoxin. Glutamate kainate receptor agonist that shows higher affinity for the kainate receptor than any other known kainic acid analog. Causes excessive excitation of neurons resulting in the depletion of energy stores, cellular edema, and death. Inhibits adenylate cyclase activity in neuronal membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
      Catalogue Number324378
      Brand Family Calbiochem®
      Synonyms25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid
      References
      ReferencesAlfonso, M., et al. 1994. Neurochem. Int. 24, 267.
      Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
      Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
      Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
      Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
      Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
      Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
      Wright, P., et al. 1989. Can. J. Chem. 67, 481.
      Product Information
      CAS number14277-97-5
      ATP CompetitiveN
      FormWhite to off-white crystaline solid
      Hill FormulaC₁₅H₂₁NO₆
      Chemical formulaC₁₅H₂₁NO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGlutamate kainate receptor
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUX9665100
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Do not freeze solutions. Stock solutions are stable for up to 24 h at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      324378 0

      Documentation

      Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      324378

      Literatur

      Übersicht
      Alfonso, M., et al. 1994. Neurochem. Int. 24, 267.
      Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
      Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
      Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
      Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
      Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
      Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
      Wright, P., et al. 1989. Can. J. Chem. 67, 481.

      Broschüre

      Titel
      Excitotoxic Glutamate Analogs Technical Bulletin
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-May-2008 RFH
      Synonyms25-[2α, 3β, 4β (1Z, 3E, 5R)]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid
      DescriptionGlutamate kainate excitatory amino acid agonist with the highest affinity for the kainate receptor of all known kainic acid analogs. It has been used to purify the kainate receptor by affinity chromatography. Its binding to the receptor causes continuous stimulation of nerve cells leading to depletion of energy, cellular edema, and death. Its neurological effect resembles anterograde memory loss associated with Alzheimer's disease. Inhibits adenylate cyclase activity in brain membranes. Evokes Ca2+-dependent and Ca2+-independent release of GABA.
      FormWhite to off-white crystaline solid
      CAS number14277-97-5
      RTECSUX9665100
      Chemical formulaC₁₅H₂₁NO₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (8 mg/ml) or Methanol (0.6 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Do not freeze solutions. Stock solutions are stable for up to 24 h at 4°C.
      Toxicity Harmful
      Merck USA index14, 3417
      ReferencesAlfonso, M., et al. 1994. Neurochem. Int. 24, 267.
      Nijjar, M.S., and Grimmelt, B. 1994. Mol. Cell. Biochem. 136, 105.
      Hampson, D.R., et al. 1992. Eur. J. Pharmacol. 218, 1.
      Usherwood, P.N., and Barnard, E.A. 1992. Comp. Biochem. Physiol. [C] 103, 19.
      Tasker, R.A.R., et al. 1991. Can. J. Physiol. Pharmacol. 69, 127.
      Stewart, G.R., et al. 1990. Exp. Neurol. 110, 127.
      Bird, C.J., and Wright, J.L.C. 1989. World Aquacult. 20, 40.
      Wright, P., et al. 1989. Can. J. Chem. 67, 481.