533982 Sigma-AldrichDock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem
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Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
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| 54129-15-6 | C₁₂H₉Cl₂NO₂S |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 5.33982.0001 |
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Glasflasche | 50 mg |
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| Description | |
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| Overview | A cell-permeable, bioavailable, non-toxic benzenesulfonamide compound that directly blocks Dock5-mediated Rac activation (kcat/KM = 7.9 x 104 & 9.5 x 104 M-1s-1 for Rac1 & Rac2 by Dock5-DHR2, respectively) with selectivity over RhoA and Cdc42. At higher concentrations, affects Dock1 and Dock2 guanine nucleotide exchange factor activity. Shown to reversibly perturb podosome organization and inhibit osteoclastic bone degradation in a dose-dependent manner. Efficiently prevents both arthritis and metastasis-induced bone loss while preserving bone formation in several osteolytic disease mouse model (25 mg/kg, i.p. or i.v., 5 days a week for 4 weeks). Unlike alendronate (Cat. No. 126855), C21 does not impair bone formation. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 533982 |
| Brand Family | Calbiochem® |
| Synonyms | N-(3,5-Dichlorophenyl)benzenesulfonamide |
| References | |
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| References | Vives, V., et al. 2015. Nat. Commun. 6, 6218. Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099. |
| Product Information | |
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| CAS number | 54129-15-6 |
| Form | Grey powder |
| Hill Formula | C₁₂H₉Cl₂NO₂S |
| Chemical formula | C₁₂H₉Cl₂NO₂S |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Dock5 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 5.33982.0001 | 04055977281729 |
Documentation
Dock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem SDB
| Titel |
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Literatur
| Übersicht |
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| Vives, V., et al. 2015. Nat. Commun. 6, 6218. Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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