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508321 Dihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem

An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC₅₀ = 12 nM).

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Synonyme: 6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785

Primary Target: DHODH
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508321
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
96201-88-6C₂₃H₁₄F₂NNaO₂

Preis & Verfügbarkeit

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5.08321.0001
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      Description
      OverviewA quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).
      Catalogue Number508321
      Brand Family Calbiochem®
      Synonyms6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785
      References
      ReferencesHe, T. et al. 2013. Oncogene 32, in press.
      Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1610.
      Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents. 38, 435.
      Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett. 14, 1549.
      Allison, A., et al. 1993. Transplantation Proc. 25, 67.
      Cramer, D. et al. 1992. Transplantation. 53, 303.
      Product Information
      CAS number96201-88-6
      FormOff-white solid
      Hill FormulaC₂₃H₁₄F₂NNaO₂
      Chemical formulaC₂₃H₁₄F₂NNaO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDHODH
      Primary Target IC<sub>50</sub>12 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5.08321.0001 04055977261899

      Documentation

      Dihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      He, T. et al. 2013. Oncogene 32, in press.
      Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1610.
      Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents. 38, 435.
      Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett. 14, 1549.
      Allison, A., et al. 1993. Transplantation Proc. 25, 67.
      Cramer, D. et al. 1992. Transplantation. 53, 303.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-January-2014 JSW
      Synonyms6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785
      DescriptionA quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number96201-88-6
      Chemical formulaC₂₃H₁₄F₂NNaO₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHe, T. et al. 2013. Oncogene 32, in press.
      Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1610.
      Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents. 38, 435.
      Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett. 14, 1549.
      Allison, A., et al. 1993. Transplantation Proc. 25, 67.
      Cramer, D. et al. 1992. Transplantation. 53, 303.