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263200 Dephostatin - CAS 151606-30-3 - Calbiochem

Dephostatin - CAS 151606-30-3 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: PTP Inhibitor VII

Primary Target: protein tyrosine phosphatase activity from human neoplastic cell line
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      151606-30-3C₇H₈N₂O₃
      Description
      Overview

      This product has been discontinued.



      Protein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line (IC50 = 7.7 µM). Reported to mobilize intracellular calcium stores. Could serve as a stable NO donor for S-nitrosylation of proteins.
      Catalogue Number263200
      Brand Family Calbiochem®
      SynonymsPTP Inhibitor VII
      References
      ReferencesLajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
      Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
      Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
      Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
      Imoto, M., et al. 1993. J. Antibiot. 46, 1342.
      Product Information
      CAS number151606-30-3
      ATP CompetitiveY
      FormBrown powder
      Hill FormulaC₇H₈N₂O₃
      Chemical formulaC₇H₈N₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetprotein tyrosine phosphatase activity from human neoplastic cell line
      Primary Target IC<sub>50</sub>7.7 µM against protein tyrosine phosphatase activity in membrane preparations from human neoplastic T cell line
      Purity≥90% by HPLC
      SourceStreptomyces sp.
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCZ9021800
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      263200 0

      Documentation

      Dephostatin - CAS 151606-30-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      263200

      Literatur

      Übersicht
      Lajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
      Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
      Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
      Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
      Imoto, M., et al. 1993. J. Antibiot. 46, 1342.

      Broschüre

      Titel
      Protein Phosphatases Technical Bulletin
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-June-2008 RFH
      SynonymsPTP Inhibitor VII
      DescriptionProtein tyrosine phosphatase inhibitor. Competitively inhibits protein tyrosine phosphatase activity in a membrane preparation from a human neoplastic T-cell line (IC50 = 7.7 µM). Inhibits homogenous recombinant Yersinia and mammalian protein tyrosine phosphatases in a concentration and time-dependent manner.
      FormBrown powder
      Intert gas (Yes/No) Packaged under inert gas
      SourceStreptomyces sp.
      CAS number151606-30-3
      RTECSCZ9021800
      Chemical formulaC₇H₈N₂O₃
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityChloroform or DMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLajas, A.I., et al. 2000. Mol. Cell Biochem. 205, 163.
      Guo, Z., et al. 1996. Bioorganic Med. Chem. Lett. 6, 573.
      Watanabe, T., et al. 1995. J. Antibiot. 48, 1460.
      Yu, L., et al. 1995. Bioorg. Med. Chem. Lett. 9, 1003.
      Imoto, M., et al. 1993. J. Antibiot. 46, 1342.