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253500 Denbufylline

A cell-permeable xanthine derivative that acts as a selective inhibitor of phosphodiesterase IV (PDE IV; Ki = ~ 1 µM).

Denbufylline: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1,3-Di-n-butyl-7-(2ʹ-oxopropyl)xanthine

Primary Target: Phosphodiesterase IV (PDE IV)
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      57076-71-8C₁₆H₂₄N₄O₃
      Description
      Overview

      This product has been discontinued.





      A cell-permeable xanthine derivative that acts as a selective inhibitor of phosphodiesterase IV (PDE IV; Ki = ~ 1 µM). Possesses bronchodilatory properties. Displays negative inotropic effect by acting on a verapamil-sensitive site of the calcium channel in guinea pig ventricle papillary muscle independently of its PDE inhibitory activity.
      Catalogue Number253500
      Brand Family Calbiochem®
      Synonyms1,3-Di-n-butyl-7-(2ʹ-oxopropyl)xanthine
      References
      ReferencesKumari, M., et al. 1997. Br. J. Pharmacol. 121, 459.
      Sanae, F., et al. 1996. J. Pharmacol. Exp. Ther. 277, 54.
      Cortijo, J., et al. 1993. Br. J. Pharmacol. 108, 562.
      Nicholson, C.D., et al. 1989. Br. J. Pharmacol. 97, 889.
      Product Information
      CAS number57076-71-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₂₄N₄O₃
      Chemical formulaC₁₆H₂₄N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPhosphodiesterase IV (PDE IV)
      Primary Target K<sub>i</sub>~ 1 µM against PDE IV
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUO8413435
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      253500 0

      Documentation

      Denbufylline Analysenzertifikate

      TitelChargennummer
      253500

      Literatur

      Übersicht
      Kumari, M., et al. 1997. Br. J. Pharmacol. 121, 459.
      Sanae, F., et al. 1996. J. Pharmacol. Exp. Ther. 277, 54.
      Cortijo, J., et al. 1993. Br. J. Pharmacol. 108, 562.
      Nicholson, C.D., et al. 1989. Br. J. Pharmacol. 97, 889.

      Broschüre

      Titel
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2008 RFH
      Synonyms1,3-Di-n-butyl-7-(2ʹ-oxopropyl)xanthine
      DescriptionA cell-permeable xanthine derivative that acts as a selective inhibitor of phosphodiesterase IV (PDE IV; Ki ~1 µM). Possesses bronchodilatory activity. Displays negative ionotropic effect by acting on a verapamil-sensitive site of the calcium channel in guinea pig ventricle papillary muscle independently of its PDE inhibitory activity.
      FormWhite solid
      CAS number57076-71-8
      RTECSUO8413435
      Chemical formulaC₁₆H₂₄N₄O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Methanol (100 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesKumari, M., et al. 1997. Br. J. Pharmacol. 121, 459.
      Sanae, F., et al. 1996. J. Pharmacol. Exp. Ther. 277, 54.
      Cortijo, J., et al. 1993. Br. J. Pharmacol. 108, 562.
      Nicholson, C.D., et al. 1989. Br. J. Pharmacol. 97, 889.