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252010 Debromohymenialdisine, Stylotella aurantium

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Synonyme: DBH

252010
  
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      Übersicht

      Replacement Information
      Description
      OverviewAn alkaloid isolated from a shallow-water marine sponge that acts as a highly selective inhibitor of G2 phase DNA damage checkpoint (IC50 = 8 µM). Exhibits moderate cytotoxicity (IC50 = 25 µM) toward MCF-7 cells. Acts by blocking the activities of checkpoint kinases Chk1 (IC50 = 3 µM) and Chk2 (IC50 = 3.5 µM). Inhibition is competitive with respect to ATP and does not affect the activities of other kinases.
      Catalogue Number252010
      Brand Family Calbiochem®
      SynonymsDBH
      References
      ReferencesCurman, D., et al. 2001. J. Biol. Chem. 276, 17914.
      Product Information
      CAS number125118-55-0
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₁H₁₁N₅O₂
      Chemical formulaC₁₁H₁₁N₅O₂
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetG2 phase DNA damage checkpoint
      Primary Target IC<sub>50</sub>8 µM
      Secondary targetChk1 (IC₅₀ = 3 µM) and Chk2 (IC₅₀ = 3.5 µM), cytotoxicity (IC₅₀ = 25 µM) toward MCF-7 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      252010 0

      Documentation

      Debromohymenialdisine, Stylotella aurantium Analysenzertifikate

      TitelChargennummer
      252010

      Literatur

      Übersicht
      Curman, D., et al. 2001. J. Biol. Chem. 276, 17914.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-December-2008 RFH
      SynonymsDBH
      DescriptionAn alkaloid isolated from a shallow-water marine sponge that acts as a highly selective blocker of the G2 phase of the cell cycle (DNA damage checkpoint) (IC50 = 8 µM). Acts by blocking the activities of the check point kinases, Chk1 (IC50 = 3 µM) and Chk2 (IC50 = 3.5 µM), thus interfering with inhibitory phosphorylation of Cdc2 kinase, resulting in its activation. The inhibition is shown to be competitive with respect to ATP. Exhibits only moderate cytotoxicity in the absence of DNA-damaging agents (IC50 = 25 µM). Does not inhibit other DNA damage checkpoint kinases such as ATM, ATR, and DNA-PK.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number125118-55-0
      Chemical formulaC₁₁H₁₁N₅O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCurman, D., et al. 2001. J. Biol. Chem. 276, 17914.