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323115 DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem

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Synonyme: 4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      101860-83-7C₉H₈BrNO₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable nitro-propiophenone compound that preferentially enhances tumor growth-inhibitory effects of ionizing radiation (~ 5 µM in U251, HT-29 and A549 tumor cells and in U251 xenograft mouse model, 50 mg/kg, i.p.) with no apparent effect on normal human glial cells, Zebrafish embryos and nude mice. Shown to increase the accumulation of unrepaired double-strand DNA breaks and prolong the damage-dependent signaling.
      Catalogue Number323115
      Brand Family Calbiochem®
      Synonyms4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123
      References
      ReferencesLally, B.E., et al. 2007. Cancer Res. 67, 8791.
      Product Information
      CAS number101860-83-7
      FormOff-white solid
      Hill FormulaC₉H₈BrNO₃
      Chemical formulaC₉H₈BrNO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      323115 0

      Documentation

      DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      323115

      Literatur

      Übersicht
      Lally, B.E., et al. 2007. Cancer Res. 67, 8791.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-August-2011 JSW
      Synonyms4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123
      DescriptionA cell-permeable nitro-propiophenone compound that preferentially enhances tumor growth-inhibitory effects of ionizing radiation (~ 5 µM in U251, HT-29 and A549 tumor cells and in U251 xenograft mouse model, 50 mg/kg, i.p.) with no apparent effect on normal human glial cells, Zebrafish embryos and nude mice. Shown to increase the accumulation of unrepaired double-strand DNA breaks and prolong the damage-dependent signaling.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number101860-83-7
      Chemical formulaC₉H₈BrNO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLally, B.E., et al. 2007. Cancer Res. 67, 8791.