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533917 Choline Transporter Inhibitor II, ML352 - CAS 1649450-12-3 - Calbiochem

A moderately brain permeant, non-choline based highly selective and potent inhibitor of high-affinity choline transporter (CHT; Ki = 92 nM in hCHT-LV-AA transfected HEK293 cells).

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Synonyme: N-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide, 4-Methoxy-3-(1-methylpiperidin-4-yl)oxy-N-((3-propan-2-yl-1,2-oxazol-5-yl)methyl)benzamide, CHT Inhibitor II, VU0476328

Primary Target: CHT
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533917
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Übersicht

Key Spec Table

CAS #Empirical Formula
1649450-12-3C₂₁H₂₉N₃O₄

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      Description
      OverviewA moderately brain permeant, non-choline based isoxazolylbenzamide compound that acts as a highly selective and potent inhibitor of high-affinity choline transporter (CHT; Ki = 92 nM in hCHT-LV-AA transfected HEK293 cells and 166 nM in mouse brain synaptosomes). The inhibition appears to be allosteric and noncompetitive. Does not affect the activity of acetylcholinesterase or cholineacetyltransferase and has no activity against dopamine, serotonin, and norepinephrine transporters. Also does not affect CHT protein expression. Exhibits high selectivity when tested against 68 GPCRs, ion channels, and transporters (IC50 > 10 µM). Displays moderate pharmacokinetic properties (t1/2= 33 min, AUC = 77.5 ng/h/ml; Cmax = 32.6 ng/ml, at 2.3 mg/kg, p.o. in Sprague-Dawley rats) and attractive solubility (98.2 µM in PBS). Does not affect the activity of cytochrome P450 and hERG (IC50 > 30 µM).
      Catalogue Number533917
      Brand Family Calbiochem®
      SynonymsN-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide, 4-Methoxy-3-(1-methylpiperidin-4-yl)oxy-N-((3-propan-2-yl-1,2-oxazol-5-yl)methyl)benzamide, CHT Inhibitor II, VU0476328
      DescriptionCholine Transporter Inhibitor II, ML352
      References
      ReferencesEnnis, E.A., et al. ACS Chem. Neurosci. 6, In press.
      Product Information
      CAS number1649450-12-3
      FormBrown solid
      Hill FormulaC₂₁H₂₉N₃O₄
      Chemical formulaC₂₁H₂₉N₃O₄
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetCHT
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      5.33917.0001 04055977281576