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227037 Cholera Toxin, A Subunit, Vibrio cholerae, Type Inaba 569B

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227037
  
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      Description
      Overview

      This product has been discontinued.

      We apologize for the inconvenience, but we do not currently have an alternative product. For related products, please refer to our complete listing of toxins.






      The subunit responsible for activation of adenylate cyclase. Binds to the ADP-ribosylation factor and modulates its activity. Catalyzes the ADP-ribosylation of the α-subunit of G-proteins, reducing intrinsic GTPase activity and activating the α-subunit.
      Catalogue Number227037
      Brand Family Calbiochem®
      References
      ReferencesMcCloskey, M.A., and Zhang, L. 2000. J. Cell. Biol. 148, 137. Tsai, S.C., et al. 1988. J. Biol. Chem. 263, 1768. Van Heynigen, S. 1982. Biosci. Rep. 2, 135. Mekalanos, J.J., et al. 1978. Infect. Immun. 20, 552. Lai, C.Y., et al. 1976. J. Infect. Dis 139, 674. Rappaport, R.S., et al. 1974. Infect. Immun. 9, 294. Craig, J.P. 1971. In Kadies, S., et al. (Eds.). Microbial Toxins. New York. Academic Press, 2A, 189.
      Product Information
      ActivityThe activity of the intact toxin is greater than or equal to that of a standard cholera toxin preparation as determined in an ADP ribosylation assay. Each lot of purified A subunit is 2-3 times more active than the intact toxin as an activator of adenylate cyclase (weight basis). In an ADP-ribosylation assay, the specific enzymatic activity of a typical lot of A subunit is approximately 2.0 times that of cholera toxin on a weight basis.
      DeclarationNot available for sale outside of the United States.
      FormSolid
      FormulationLyophilized from 200 mM NaCl, 50 mM Tris, 3 mM NaN₃, 1 mM EDTA, pH 7.5.
      Physicochemical Information
      ContaminantsB subunit and intact toxin: none detected by native PAGE
      Safety Information
      R PhraseR: 21/22-36/37/38

      Harmful in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 7-36/37

      Keep container tightly closed.
      Wear suitable protective clothing and gloves.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Yes
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
      End use certificateY
      Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
      Global Trade Item Number
      Bestellnummer GTIN
      227037 0