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219493 Ceramide Kinase Inhibitor II, NVP-231 - Calbiochem

The Ceramide Kinase Inhibitor II, NVP-231 controls the biological activity of Ceramide Kinase. This small molecule/inhibitor is primarily used for Membrane applications.

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Synonyme: Adamantane-1-carboxylic acid-(2-benzoylamino-benzothiazol-6-yl)-amide, CerK Inhibitor II, NVP-231

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₅H₂₆N₃O₂S
      Description
      OverviewA cell-permeable benzothiazole compound that potently inhibits Cer (ceramide) phosphorylation by CerK (Cer Kinase) in a reversible and Cer-, but not ATP-, competitive manner (IC50 = 12 nM; Ki = 7.4 nM) with excellent selectivity over hDAGKα (IC50 = 5 µM) and little or no activity against eight other lipid metabolizing enzymes and kinases (IC50 ≥10 µM) in cell-free enzymatic assays. When applied to live cells in cultures, NVP-231 effectively prevents the binding of Cer to CerK, making cellular Cer more available to other Cer metabolizing enzymes and resulting in an increased GlcCer (glucosylceramide) and SM (sphingomyelin) production in addition to the expected decrease of Cer phosphorylation.
      Catalogue Number219493
      Brand Family Calbiochem®
      SynonymsAdamantane-1-carboxylic acid-(2-benzoylamino-benzothiazol-6-yl)-amide, CerK Inhibitor II, NVP-231
      References
      ReferencesGraf, C., et al. 2008. Mol. Pharmacol. 74, 925.
      Product Information
      FormTan solid
      Hill FormulaC₂₅H₂₆N₃O₂S
      Chemical formulaC₂₅H₂₆N₃O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      219493 0

      Documentation

      Ceramide Kinase Inhibitor II, NVP-231 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Ceramide Kinase Inhibitor II, NVP-231 - Calbiochem Analysenzertifikate

      TitelChargennummer
      219493

      Literatur

      Übersicht
      Graf, C., et al. 2008. Mol. Pharmacol. 74, 925.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2011 RFH
      SynonymsAdamantane-1-carboxylic acid-(2-benzoylamino-benzothiazol-6-yl)-amide, CerK Inhibitor II, NVP-231
      DescriptionA cell-permeable benzothiazole compound that potently inhibits Cer (ceramide) phosphorylation by CerK (Cer Kinase) in a reversible and Cer-, but not ATP-, competitive manner (IC50 = 12 nM; Ki = 7.4 nM) with excellent selectivity over hDAGKα (IC50 = 5 µM) and little or no activity against eight other lipid metabolizing enzymes and kinases (IC50 ≥10 µM) in cell-free enzymatic assays. When applied to live cells in cultures, NVP-231 effectively prevents the binding of Cer to CerK, making cellular Cer more available to other Cer metabolizing enzymes and resulting in an increased GlcCer (glucosylceramide) and SM (sphingomyelin) production in addition to the expected decrease of Cer phosphorylation.
      FormTan solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₂₆N₃O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGraf, C., et al. 2008. Mol. Pharmacol. 74, 925.