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238804 Cdk2 Inhibitor IV, NU6140 - CAS 444723-13-1 - Calbiochem

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Synonyme: 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide, Cdk7 Inhibitor II

Primary Target: Cdk1/cyclin B
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      444723-13-1C₂₃H₃₀N₆O₂
      Description
      Overview

      This product has been discontinued.



      A highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC50 = 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulation survivin. Synergistically potentiates paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.
      Catalogue Number238804
      Brand Family Calbiochem®
      Synonyms4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide, Cdk7 Inhibitor II
      References
      ReferencesPennati, M., et al. 2005. Mol. Cancer Ther. 4, 1328.
      Product Information
      CAS number444723-13-1
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₂₃H₃₀N₆O₂
      Chemical formulaC₂₃H₃₀N₆O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1/cyclin B
      Primary Target IC<sub>50</sub>6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      238804 0

      Documentation

      Cdk2 Inhibitor IV, NU6140 - CAS 444723-13-1 - Calbiochem Analysenzertifikate

      TitelChargennummer
      238804

      Literatur

      Übersicht
      Pennati, M., et al. 2005. Mol. Cancer Ther. 4, 1328.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-October-2007 JSW
      Synonyms4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide, Cdk7 Inhibitor II
      DescriptionA highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC50 = 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulation survivin. Synergistically potentiates paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number444723-13-1
      Chemical formulaC₂₃H₃₀N₆O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesPennati, M., et al. 2005. Mol. Cancer Ther. 4, 1328.